Vector Field Heterogeneity for the Assessment of Locally Disorganised Cardiac Electrical Propagation Wavefronts From High-Density Multielectrodes
High-density multielectrode catheters are becoming increasingly popular in cardiac electrophysiology for advanced characterisation of the cardiac tissue, due to their potential to identify impaired sites. These are often characterised by abnormal electrical conduction, which may cause locally disorg...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IEEE
2024-01-01
|
| Series: | IEEE Open Journal of Engineering in Medicine and Biology |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/10367768/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582328251056128 |
|---|---|
| author | Lucia Pancorbo Samuel Ruiperez-Campillo Alvaro Tormos Antonio Guill Raquel Cervigon Antonio Alberola Francisco Javier Chorro Jose Millet Francisco Castells |
| author_facet | Lucia Pancorbo Samuel Ruiperez-Campillo Alvaro Tormos Antonio Guill Raquel Cervigon Antonio Alberola Francisco Javier Chorro Jose Millet Francisco Castells |
| author_sort | Lucia Pancorbo |
| collection | DOAJ |
| description | High-density multielectrode catheters are becoming increasingly popular in cardiac electrophysiology for advanced characterisation of the cardiac tissue, due to their potential to identify impaired sites. These are often characterised by abnormal electrical conduction, which may cause locally disorganised propagation wavefronts. To quantify it, a novel heterogeneity parameter based on vector field analysis is proposed, utilising finite differences to measure direction changes between adjacent cliques. The proposed Vector Field Heterogeneity metric has been evaluated on a set of simulations with controlled levels of organisation in vector maps, and a variety of grid sizes. Furthermore, it has been tested on animal experimental models of isolated Langendorff-perfused rabbit hearts. The proposed parameter exhibited superior capturing ability of heterogeneous propagation wavefronts compared to the classical Spatial Inhomogeneity Index, and simulations proved that the metric effectively captures gradual increments in disorganisation in propagation patterns. Notably, it yielded robust and consistent outcomes for <inline-formula><tex-math notation="LaTeX">$\mathbf {4\times 4}$</tex-math></inline-formula> grid sizes, underscoring its suitability for the latest generation of orientation-independent cardiac catheters. |
| format | Article |
| id | doaj-art-a9779179bc8a4c3fb0dd7aa91516a53c |
| institution | Kabale University |
| issn | 2644-1276 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Open Journal of Engineering in Medicine and Biology |
| spelling | doaj-art-a9779179bc8a4c3fb0dd7aa91516a53c2025-01-30T00:03:38ZengIEEEIEEE Open Journal of Engineering in Medicine and Biology2644-12762024-01-015324410.1109/OJEMB.2023.334434910367768Vector Field Heterogeneity for the Assessment of Locally Disorganised Cardiac Electrical Propagation Wavefronts From High-Density MultielectrodesLucia Pancorbo0https://orcid.org/0009-0005-7788-5024Samuel Ruiperez-Campillo1https://orcid.org/0000-0002-5425-4175Alvaro Tormos2https://orcid.org/0000-0002-3280-376XAntonio Guill3https://orcid.org/0000-0001-8546-264XRaquel Cervigon4https://orcid.org/0000-0002-0439-6589Antonio Alberola5https://orcid.org/0000-0001-8531-4161Francisco Javier Chorro6https://orcid.org/0000-0002-4613-5459Jose Millet7https://orcid.org/0000-0002-8879-003XFrancisco Castells8https://orcid.org/0000-0001-5044-3545ITACA Institute, Universitat Politècnica de València, Valencia, SpainITACA Institute, Universitat Politècnica de València, Valencia, SpainITACA Institute, Universitat Politècnica de València, Valencia, SpainITACA Institute, Universitat Politècnica de València, Valencia, SpainUniversidad de Castilla-La Mancha, Cuenca, SpainDepartamento de Fisiología, Universidad de València, Valencia, SpainCIBER E. Cardiovasculares, Madrid, SpainITACA Institute, Universitat Politècnica de València, Valencia, SpainITACA Institute, Universitat Politècnica de València, Valencia, SpainHigh-density multielectrode catheters are becoming increasingly popular in cardiac electrophysiology for advanced characterisation of the cardiac tissue, due to their potential to identify impaired sites. These are often characterised by abnormal electrical conduction, which may cause locally disorganised propagation wavefronts. To quantify it, a novel heterogeneity parameter based on vector field analysis is proposed, utilising finite differences to measure direction changes between adjacent cliques. The proposed Vector Field Heterogeneity metric has been evaluated on a set of simulations with controlled levels of organisation in vector maps, and a variety of grid sizes. Furthermore, it has been tested on animal experimental models of isolated Langendorff-perfused rabbit hearts. The proposed parameter exhibited superior capturing ability of heterogeneous propagation wavefronts compared to the classical Spatial Inhomogeneity Index, and simulations proved that the metric effectively captures gradual increments in disorganisation in propagation patterns. Notably, it yielded robust and consistent outcomes for <inline-formula><tex-math notation="LaTeX">$\mathbf {4\times 4}$</tex-math></inline-formula> grid sizes, underscoring its suitability for the latest generation of orientation-independent cardiac catheters.https://ieeexplore.ieee.org/document/10367768/Animal experimental modelscardiac signal processingelectrophysiologyhigh-density electrode cathetersvector field heterogeneity |
| spellingShingle | Lucia Pancorbo Samuel Ruiperez-Campillo Alvaro Tormos Antonio Guill Raquel Cervigon Antonio Alberola Francisco Javier Chorro Jose Millet Francisco Castells Vector Field Heterogeneity for the Assessment of Locally Disorganised Cardiac Electrical Propagation Wavefronts From High-Density Multielectrodes IEEE Open Journal of Engineering in Medicine and Biology Animal experimental models cardiac signal processing electrophysiology high-density electrode catheters vector field heterogeneity |
| title | Vector Field Heterogeneity for the Assessment of Locally Disorganised Cardiac Electrical Propagation Wavefronts From High-Density Multielectrodes |
| title_full | Vector Field Heterogeneity for the Assessment of Locally Disorganised Cardiac Electrical Propagation Wavefronts From High-Density Multielectrodes |
| title_fullStr | Vector Field Heterogeneity for the Assessment of Locally Disorganised Cardiac Electrical Propagation Wavefronts From High-Density Multielectrodes |
| title_full_unstemmed | Vector Field Heterogeneity for the Assessment of Locally Disorganised Cardiac Electrical Propagation Wavefronts From High-Density Multielectrodes |
| title_short | Vector Field Heterogeneity for the Assessment of Locally Disorganised Cardiac Electrical Propagation Wavefronts From High-Density Multielectrodes |
| title_sort | vector field heterogeneity for the assessment of locally disorganised cardiac electrical propagation wavefronts from high density multielectrodes |
| topic | Animal experimental models cardiac signal processing electrophysiology high-density electrode catheters vector field heterogeneity |
| url | https://ieeexplore.ieee.org/document/10367768/ |
| work_keys_str_mv | AT luciapancorbo vectorfieldheterogeneityfortheassessmentoflocallydisorganisedcardiacelectricalpropagationwavefrontsfromhighdensitymultielectrodes AT samuelruiperezcampillo vectorfieldheterogeneityfortheassessmentoflocallydisorganisedcardiacelectricalpropagationwavefrontsfromhighdensitymultielectrodes AT alvarotormos vectorfieldheterogeneityfortheassessmentoflocallydisorganisedcardiacelectricalpropagationwavefrontsfromhighdensitymultielectrodes AT antonioguill vectorfieldheterogeneityfortheassessmentoflocallydisorganisedcardiacelectricalpropagationwavefrontsfromhighdensitymultielectrodes AT raquelcervigon vectorfieldheterogeneityfortheassessmentoflocallydisorganisedcardiacelectricalpropagationwavefrontsfromhighdensitymultielectrodes AT antonioalberola vectorfieldheterogeneityfortheassessmentoflocallydisorganisedcardiacelectricalpropagationwavefrontsfromhighdensitymultielectrodes AT franciscojavierchorro vectorfieldheterogeneityfortheassessmentoflocallydisorganisedcardiacelectricalpropagationwavefrontsfromhighdensitymultielectrodes AT josemillet vectorfieldheterogeneityfortheassessmentoflocallydisorganisedcardiacelectricalpropagationwavefrontsfromhighdensitymultielectrodes AT franciscocastells vectorfieldheterogeneityfortheassessmentoflocallydisorganisedcardiacelectricalpropagationwavefrontsfromhighdensitymultielectrodes |