TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models
A considerable body of experimental evidence suggests that tumor necrosis factor (TNF)-α plays a major role in several aspects of inflammation and shock. In particular, it is pivotal in many detrimental effects of acute pancreatitis, and it represents a major determinant of the systemic progression...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.98 |
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| author | Giuseppe Malleo Emanuela Mazzon Ajith K. Siriwardena Salvatore Cuzzocrea |
| author_facet | Giuseppe Malleo Emanuela Mazzon Ajith K. Siriwardena Salvatore Cuzzocrea |
| author_sort | Giuseppe Malleo |
| collection | DOAJ |
| description | A considerable body of experimental evidence suggests that tumor necrosis factor (TNF)-α plays a major role in several aspects of inflammation and shock. In particular, it is pivotal in many detrimental effects of acute pancreatitis, and it represents a major determinant of the systemic progression and end-organ damage (such as acute lung injury and liver failure) of this pathologic condition. Given the importance of TNF-α in the pathogenesis of acute pancreatitis, investigators have regarded blocking the action of this mediator as an attractive treatment option. Different specific and nonspecific inhibitors have been developed with promising results in animal models, but, on the other hand, no clinical trials have been designed so far. Difficulties in clinical applications may be multifactorial; experimental models are not fully reliable and reproduce at least some aspects of human disease, timing of intervention should be related to changes in TNF-α serum levels, and inclusion criteria should be accurately selected to better define the population most likely to benefit. |
| format | Article |
| id | doaj-art-a96eb6d95386455cbcb1ad86fe42a428 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a96eb6d95386455cbcb1ad86fe42a4282025-02-03T01:32:53ZengWileyThe Scientific World Journal1537-744X2007-01-01743144810.1100/tsw.2007.98TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental ModelsGiuseppe Malleo0Emanuela Mazzon1Ajith K. Siriwardena2Salvatore Cuzzocrea3Department of Clinical, Experimental Medicine and Pharmacology, School of Medicine, University of Messina, ItalyDepartment of Clinical, Experimental Medicine and Pharmacology, School of Medicine, University of Messina, ItalyDepartment of Surgery, Hepatobiliary Unit, Manchester Royal Infirmary, Manchester, UKDepartment of Clinical, Experimental Medicine and Pharmacology, School of Medicine, University of Messina, ItalyA considerable body of experimental evidence suggests that tumor necrosis factor (TNF)-α plays a major role in several aspects of inflammation and shock. In particular, it is pivotal in many detrimental effects of acute pancreatitis, and it represents a major determinant of the systemic progression and end-organ damage (such as acute lung injury and liver failure) of this pathologic condition. Given the importance of TNF-α in the pathogenesis of acute pancreatitis, investigators have regarded blocking the action of this mediator as an attractive treatment option. Different specific and nonspecific inhibitors have been developed with promising results in animal models, but, on the other hand, no clinical trials have been designed so far. Difficulties in clinical applications may be multifactorial; experimental models are not fully reliable and reproduce at least some aspects of human disease, timing of intervention should be related to changes in TNF-α serum levels, and inclusion criteria should be accurately selected to better define the population most likely to benefit.http://dx.doi.org/10.1100/tsw.2007.98 |
| spellingShingle | Giuseppe Malleo Emanuela Mazzon Ajith K. Siriwardena Salvatore Cuzzocrea TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models The Scientific World Journal |
| title | TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models |
| title_full | TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models |
| title_fullStr | TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models |
| title_full_unstemmed | TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models |
| title_short | TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models |
| title_sort | tnf α as a therapeutic target in acute pancreatitis lessons from experimental models |
| url | http://dx.doi.org/10.1100/tsw.2007.98 |
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