Corticosteroids in Patients with IgA Nephropathy and Severe Chronic Renal Damage
Little is known about the utility of treating patients with advanced IgA nephropathy (IgAN). From 2001 to 2005, four patients came to our observation because of serum creatinine higher than 3 mg/dL, proteinuria ranging from 1.8 to 5.1 g/day, and a histological picture of diffuse sclerotic lesions. A...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2012/180691 |
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| author | Claudio Pozzi Francesca Ferrario Bianca Visciano Lucia Del Vecchio |
| author_facet | Claudio Pozzi Francesca Ferrario Bianca Visciano Lucia Del Vecchio |
| author_sort | Claudio Pozzi |
| collection | DOAJ |
| description | Little is known about the utility of treating patients with advanced IgA nephropathy (IgAN). From 2001 to 2005, four patients came to our observation because of serum creatinine higher than 3 mg/dL, proteinuria ranging from 1.8 to 5.1 g/day, and a histological picture of diffuse sclerotic lesions. A corticosteroid course of 12 months was given. Patients were observed for a mean follow up of 84 months. At the end of the steroid course, proteinuria lowered quickly below 1 g/day in two patients, whereas the other two experienced a slower and less persistent decrease of proteinuria. Despite similar lesion severity at renal biopsy, renal function stabilized only in these two ones. In conclusion, these preliminary observations suggest a possible efficacy of corticosteroids in slowing down the progression of renal disease and in postponing the need of dialysis in IgAN patients with stage IV CKD and severe chronic histological lesions. |
| format | Article |
| id | doaj-art-a96def46ad28485b83765a13d85c1013 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-a96def46ad28485b83765a13d85c10132025-02-03T05:53:49ZengWileyCase Reports in Nephrology2090-66412090-665X2012-01-01201210.1155/2012/180691180691Corticosteroids in Patients with IgA Nephropathy and Severe Chronic Renal DamageClaudio Pozzi0Francesca Ferrario1Bianca Visciano2Lucia Del Vecchio3Department of Nephrology and Dialysis, “Bassini” Hospital, Via Gorki 50, 20092 Cinisello Balsamo, ItalyDepartment of Nephrology and Dialysis, “Bassini” Hospital, Via Gorki 50, 20092 Cinisello Balsamo, ItalyDepartment of Nephrology and Dialysis, “Bassini” Hospital, Via Gorki 50, 20092 Cinisello Balsamo, ItalyDepartment of Nephrology, Dialysis, and Renal Transplant, Alessandro Manzoni Hospital, Via dell’Eremo 9, 23900 Lecco, ItalyLittle is known about the utility of treating patients with advanced IgA nephropathy (IgAN). From 2001 to 2005, four patients came to our observation because of serum creatinine higher than 3 mg/dL, proteinuria ranging from 1.8 to 5.1 g/day, and a histological picture of diffuse sclerotic lesions. A corticosteroid course of 12 months was given. Patients were observed for a mean follow up of 84 months. At the end of the steroid course, proteinuria lowered quickly below 1 g/day in two patients, whereas the other two experienced a slower and less persistent decrease of proteinuria. Despite similar lesion severity at renal biopsy, renal function stabilized only in these two ones. In conclusion, these preliminary observations suggest a possible efficacy of corticosteroids in slowing down the progression of renal disease and in postponing the need of dialysis in IgAN patients with stage IV CKD and severe chronic histological lesions.http://dx.doi.org/10.1155/2012/180691 |
| spellingShingle | Claudio Pozzi Francesca Ferrario Bianca Visciano Lucia Del Vecchio Corticosteroids in Patients with IgA Nephropathy and Severe Chronic Renal Damage Case Reports in Nephrology |
| title | Corticosteroids in Patients with IgA Nephropathy and Severe Chronic Renal Damage |
| title_full | Corticosteroids in Patients with IgA Nephropathy and Severe Chronic Renal Damage |
| title_fullStr | Corticosteroids in Patients with IgA Nephropathy and Severe Chronic Renal Damage |
| title_full_unstemmed | Corticosteroids in Patients with IgA Nephropathy and Severe Chronic Renal Damage |
| title_short | Corticosteroids in Patients with IgA Nephropathy and Severe Chronic Renal Damage |
| title_sort | corticosteroids in patients with iga nephropathy and severe chronic renal damage |
| url | http://dx.doi.org/10.1155/2012/180691 |
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