Pharmacokinetics, Mass Balance, and Biotransformation of [14C]tinengotinib, A Novel Multi-target Kinase Inhibitor, in Healthy Subjects
Abstract Background and Objective Tinengotinib, a novel multi-target small molecule kinase inhibitor, is currently undergoing phase II clinical trial in the USA and China. The purpose of this open-label study was to investigate the absorption, metabolism, and excretion of [14C]tinengotinib following...
Saved in:
| Main Authors: | Shumao Ni, Sheng Ma, Yingying Yu, Zhenwen Yu, Yujia Zhu, Xiaofen Sun, Lin Li, Caixia Sun, Hui Wang, Peng Peng, Zheming Gu, Hua Zhang, Frank Wu, Liyan Miao, Jean Fan |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Adis, Springer Healthcare
2024-09-01
|
| Series: | Drugs in R&D |
| Online Access: | https://doi.org/10.1007/s40268-024-00486-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Comparison of In Vitro Biotransformation of Olive Polyphenols Between Healthy Young and Elderly
by: Stef Lauwers, et al.
Published: (2025-01-01) -
Technical research and application prospects of lignocellulose biotransformation
by: PAN Runze, et al.
Published: (2024-04-01) -
Distinct bacterial community structures and arsenic biotransformation gene profiles in dust
by: Yi Yin, et al.
Published: (2025-07-01) -
Biotransformation of Hydrocortisone
by Neurospora crassa
Published: (2006-12-01) -
Stereoselectivity in Enzymic Biotransformation of Chiral and Achiral 1,3-Dihydro-2H-1,4-Benzodiazepin-2-ones
by: S. Rendić, et al.
Published: (1974-05-01)