Influenza A H1N1 Community-Acquired Pneumonia: Characteristics and Risk Factors—A Case-Control Study
Introduction. Influenza A H1N1 community-acquired pneumonia (CAP) is a quite frequent respiratory disease. Despite being considered more serious than other CAPs, there are very few studies comparing its characteristics with noninfluenza CAP. We aim to establish the differences between pneumonia due...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2019/4301039 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560131555983360 |
|---|---|
| author | Romina Abelleira Alberto Ruano-Ravina Adriana Lama Gema Barbeito María E. Toubes Cristina Domínguez-Antelo Francisco J. González-Barcala Nuria Rodríguez-Núñez Pedro J. Marcos María L. Pérez del Molino Luis Valdés |
| author_facet | Romina Abelleira Alberto Ruano-Ravina Adriana Lama Gema Barbeito María E. Toubes Cristina Domínguez-Antelo Francisco J. González-Barcala Nuria Rodríguez-Núñez Pedro J. Marcos María L. Pérez del Molino Luis Valdés |
| author_sort | Romina Abelleira |
| collection | DOAJ |
| description | Introduction. Influenza A H1N1 community-acquired pneumonia (CAP) is a quite frequent respiratory disease. Despite being considered more serious than other CAPs, there are very few studies comparing its characteristics with noninfluenza CAP. We aim to establish the differences between pneumonia due to H1N1 virus and pneumonia not caused by H1N1 influenza virus and to determine the probability that a pneumonia is due to an H1N1 virus infection based on the most relevant variables. Methods. We used a case-control study where cases were H1N1 CAP patients with confirmed microbiological diagnosis and controls were patients with CAP admitted to hospital. H1N1 and other influenza types were discarded among controls. We calculated the probability of being a case or control using multivariate logistic regression. Results. We included 99 cases and 270 controls. Cases were younger than controls (53 vs 71 years, respectively). Mortality was much higher for H1N1 patients (13% vs 0.3%), and admission to intensive care unit was more frequent for H1N1 cases. The variables most associated with presenting H1N1 CAP were bilateral affectation on chest X-rays (OR: 5.70; 95% CI 2.69–10.40), followed by presence of arthromyalgias, with cases presenting close to three times more arthromyalgias compared to controls. Low leukocytes count and high AST values were also significantly associated with H1N1 CAP. H1N1 CAPs are characterized by bilateral affectation, low leukocyte count, presence of arthromyalgias, and high AST. Conclusions. A few and easy to obtain clinical parameters might be extremely useful to distinguish H1N1 CAP from CAPs of other origin. |
| format | Article |
| id | doaj-art-a9656595585a4acf9498a6c3315b2e5f |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-a9656595585a4acf9498a6c3315b2e5f2025-02-03T01:28:25ZengWileyCanadian Respiratory Journal1198-22411916-72452019-01-01201910.1155/2019/43010394301039Influenza A H1N1 Community-Acquired Pneumonia: Characteristics and Risk Factors—A Case-Control StudyRomina Abelleira0Alberto Ruano-Ravina1Adriana Lama2Gema Barbeito3María E. Toubes4Cristina Domínguez-Antelo5Francisco J. González-Barcala6Nuria Rodríguez-Núñez7Pedro J. Marcos8María L. Pérez del Molino9Luis Valdés10Service of Pneumology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, SpainDepartment of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, SpainService of Pneumology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, SpainService of Microbiology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, SpainService of Pneumology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, SpainCritical Care Department, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, SpainService of Pneumology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, SpainService of Pneumology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, SpainService of Pneumology, University Hospital of A Coruña, A Coruña, SpainService of Microbiology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, SpainService of Pneumology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, SpainIntroduction. Influenza A H1N1 community-acquired pneumonia (CAP) is a quite frequent respiratory disease. Despite being considered more serious than other CAPs, there are very few studies comparing its characteristics with noninfluenza CAP. We aim to establish the differences between pneumonia due to H1N1 virus and pneumonia not caused by H1N1 influenza virus and to determine the probability that a pneumonia is due to an H1N1 virus infection based on the most relevant variables. Methods. We used a case-control study where cases were H1N1 CAP patients with confirmed microbiological diagnosis and controls were patients with CAP admitted to hospital. H1N1 and other influenza types were discarded among controls. We calculated the probability of being a case or control using multivariate logistic regression. Results. We included 99 cases and 270 controls. Cases were younger than controls (53 vs 71 years, respectively). Mortality was much higher for H1N1 patients (13% vs 0.3%), and admission to intensive care unit was more frequent for H1N1 cases. The variables most associated with presenting H1N1 CAP were bilateral affectation on chest X-rays (OR: 5.70; 95% CI 2.69–10.40), followed by presence of arthromyalgias, with cases presenting close to three times more arthromyalgias compared to controls. Low leukocytes count and high AST values were also significantly associated with H1N1 CAP. H1N1 CAPs are characterized by bilateral affectation, low leukocyte count, presence of arthromyalgias, and high AST. Conclusions. A few and easy to obtain clinical parameters might be extremely useful to distinguish H1N1 CAP from CAPs of other origin.http://dx.doi.org/10.1155/2019/4301039 |
| spellingShingle | Romina Abelleira Alberto Ruano-Ravina Adriana Lama Gema Barbeito María E. Toubes Cristina Domínguez-Antelo Francisco J. González-Barcala Nuria Rodríguez-Núñez Pedro J. Marcos María L. Pérez del Molino Luis Valdés Influenza A H1N1 Community-Acquired Pneumonia: Characteristics and Risk Factors—A Case-Control Study Canadian Respiratory Journal |
| title | Influenza A H1N1 Community-Acquired Pneumonia: Characteristics and Risk Factors—A Case-Control Study |
| title_full | Influenza A H1N1 Community-Acquired Pneumonia: Characteristics and Risk Factors—A Case-Control Study |
| title_fullStr | Influenza A H1N1 Community-Acquired Pneumonia: Characteristics and Risk Factors—A Case-Control Study |
| title_full_unstemmed | Influenza A H1N1 Community-Acquired Pneumonia: Characteristics and Risk Factors—A Case-Control Study |
| title_short | Influenza A H1N1 Community-Acquired Pneumonia: Characteristics and Risk Factors—A Case-Control Study |
| title_sort | influenza a h1n1 community acquired pneumonia characteristics and risk factors a case control study |
| url | http://dx.doi.org/10.1155/2019/4301039 |
| work_keys_str_mv | AT rominaabelleira influenzaah1n1communityacquiredpneumoniacharacteristicsandriskfactorsacasecontrolstudy AT albertoruanoravina influenzaah1n1communityacquiredpneumoniacharacteristicsandriskfactorsacasecontrolstudy AT adrianalama influenzaah1n1communityacquiredpneumoniacharacteristicsandriskfactorsacasecontrolstudy AT gemabarbeito influenzaah1n1communityacquiredpneumoniacharacteristicsandriskfactorsacasecontrolstudy AT mariaetoubes influenzaah1n1communityacquiredpneumoniacharacteristicsandriskfactorsacasecontrolstudy AT cristinadominguezantelo influenzaah1n1communityacquiredpneumoniacharacteristicsandriskfactorsacasecontrolstudy AT franciscojgonzalezbarcala influenzaah1n1communityacquiredpneumoniacharacteristicsandriskfactorsacasecontrolstudy AT nuriarodrigueznunez influenzaah1n1communityacquiredpneumoniacharacteristicsandriskfactorsacasecontrolstudy AT pedrojmarcos influenzaah1n1communityacquiredpneumoniacharacteristicsandriskfactorsacasecontrolstudy AT marialperezdelmolino influenzaah1n1communityacquiredpneumoniacharacteristicsandriskfactorsacasecontrolstudy AT luisvaldes influenzaah1n1communityacquiredpneumoniacharacteristicsandriskfactorsacasecontrolstudy |