Diminished Expression of Complement Regulatory Proteins on Peripheral Blood Cells from Systemic Lupus Erythematosus Patients
CD55, CD59, CD46, and CD35 are proteins with complement regulatory (Creg) properties that ensure cell and tissue integrity when this system is activated. The aim of this study was to evaluate the Creg expression on peripheral blood cells from SLE patients and its association with cytopenia and disea...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/725684 |
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| author | Ana Paula Alegretti Laiana Schneider Amanda Kirchner Piccoli Odirlei Andre Monticielo Priscila Schmidt Lora João Carlos Tavares Brenol Ricardo Machado Xavier |
| author_facet | Ana Paula Alegretti Laiana Schneider Amanda Kirchner Piccoli Odirlei Andre Monticielo Priscila Schmidt Lora João Carlos Tavares Brenol Ricardo Machado Xavier |
| author_sort | Ana Paula Alegretti |
| collection | DOAJ |
| description | CD55, CD59, CD46, and CD35 are proteins with complement regulatory (Creg) properties that ensure cell and tissue integrity when this system is activated. The aim of this study was to evaluate the Creg expression on peripheral blood cells from SLE patients and its association with cytopenia and disease activity. Flow cytometric analyses were performed on blood cells from 100 SLE patients and 61 healthy controls. Compared with healthy controls, we observed in SLE patients with lymphopenia and neutropenia decreased expression of CD55, CD59, and CD46 (𝑃<0.05). In SLE patients with anemia, CD59 and CD35 were decreased on red blood cells. Furthermore, there was a negative correlation between CD55 and CD59 on neutrophils and the disease activity. The results suggest there is an altered pattern of Creg expression on the peripheral blood cells of SLE patients, and the expression is correlated with disease activity and/or with activation of the complement system. |
| format | Article |
| id | doaj-art-a95e0775cb1f4541bd824c6d4da6304f |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-a95e0775cb1f4541bd824c6d4da6304f2025-02-03T01:30:59ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/725684725684Diminished Expression of Complement Regulatory Proteins on Peripheral Blood Cells from Systemic Lupus Erythematosus PatientsAna Paula Alegretti0Laiana Schneider1Amanda Kirchner Piccoli2Odirlei Andre Monticielo3Priscila Schmidt Lora4João Carlos Tavares Brenol5Ricardo Machado Xavier6Serviço de Patologia Clínica, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 2° Andar, 90035-903 Porto Alegre, RS, BrazilServiço de Patologia Clínica, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 2° Andar, 90035-903 Porto Alegre, RS, BrazilServiço de Patologia Clínica, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 2° Andar, 90035-903 Porto Alegre, RS, BrazilServiço de Reumatologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 6° Andar, 90035-903 Porto Alegre, RS, BrazilServiço de Reumatologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 6° Andar, 90035-903 Porto Alegre, RS, BrazilServiço de Reumatologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 6° Andar, 90035-903 Porto Alegre, RS, BrazilServiço de Reumatologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 6° Andar, 90035-903 Porto Alegre, RS, BrazilCD55, CD59, CD46, and CD35 are proteins with complement regulatory (Creg) properties that ensure cell and tissue integrity when this system is activated. The aim of this study was to evaluate the Creg expression on peripheral blood cells from SLE patients and its association with cytopenia and disease activity. Flow cytometric analyses were performed on blood cells from 100 SLE patients and 61 healthy controls. Compared with healthy controls, we observed in SLE patients with lymphopenia and neutropenia decreased expression of CD55, CD59, and CD46 (𝑃<0.05). In SLE patients with anemia, CD59 and CD35 were decreased on red blood cells. Furthermore, there was a negative correlation between CD55 and CD59 on neutrophils and the disease activity. The results suggest there is an altered pattern of Creg expression on the peripheral blood cells of SLE patients, and the expression is correlated with disease activity and/or with activation of the complement system.http://dx.doi.org/10.1155/2012/725684 |
| spellingShingle | Ana Paula Alegretti Laiana Schneider Amanda Kirchner Piccoli Odirlei Andre Monticielo Priscila Schmidt Lora João Carlos Tavares Brenol Ricardo Machado Xavier Diminished Expression of Complement Regulatory Proteins on Peripheral Blood Cells from Systemic Lupus Erythematosus Patients Clinical and Developmental Immunology |
| title | Diminished Expression of Complement Regulatory Proteins on Peripheral Blood Cells from Systemic Lupus Erythematosus Patients |
| title_full | Diminished Expression of Complement Regulatory Proteins on Peripheral Blood Cells from Systemic Lupus Erythematosus Patients |
| title_fullStr | Diminished Expression of Complement Regulatory Proteins on Peripheral Blood Cells from Systemic Lupus Erythematosus Patients |
| title_full_unstemmed | Diminished Expression of Complement Regulatory Proteins on Peripheral Blood Cells from Systemic Lupus Erythematosus Patients |
| title_short | Diminished Expression of Complement Regulatory Proteins on Peripheral Blood Cells from Systemic Lupus Erythematosus Patients |
| title_sort | diminished expression of complement regulatory proteins on peripheral blood cells from systemic lupus erythematosus patients |
| url | http://dx.doi.org/10.1155/2012/725684 |
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