High Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome
Objective. Asprosin, a new adipocytokine, has reportedly been associated with glucose release, dyslipidemia, and insulin resistance (IR). However, the relationship of asprosin with metabolic syndrome (MetS) remains unknown. This study aimed to investigate serum asprosin levels in MetS as well as the...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/6622129 |
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| author | Tao Hong Jiao-Yang Li Ya-Di Wang Xiao-Yan Qi Zhe-Zhen Liao Poonam Bhadel Li Ran Jing Yang Bin Yan Jiang-Hua Liu Xin-Hua Xiao |
| author_facet | Tao Hong Jiao-Yang Li Ya-Di Wang Xiao-Yan Qi Zhe-Zhen Liao Poonam Bhadel Li Ran Jing Yang Bin Yan Jiang-Hua Liu Xin-Hua Xiao |
| author_sort | Tao Hong |
| collection | DOAJ |
| description | Objective. Asprosin, a new adipocytokine, has reportedly been associated with glucose release, dyslipidemia, and insulin resistance (IR). However, the relationship of asprosin with metabolic syndrome (MetS) remains unknown. This study aimed to investigate serum asprosin levels in MetS as well as their association with various metabolic parameters in humans. Methods. A total of 131 consecutive patients with MetS, and 162 age-matched, healthy subjects were recruited for this study. Serum asprosin concentrations were determined using the enzyme-linked immunosorbent assay. Lipid profile, glucose, insulin, and inflammatory markers were also measured. Results. Serum asprosin levels were higher in subjects with MetS (23.52 [16.70, 32.05] ng/mL) than in controls (16.70 [12.87, 22.38] ng/mL; P<0.01), and they showed an increasing trend with increasing numbers of metabolic components (P for trend < 0.01). In all studied subjects, serum asprosin levels were positively correlated with body mass index, waist circumference, triglycerides, fasting plasma glucose, 2-hour plasma glucose, fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR) index, interleukin-6, and monocyte chemoattractant protein-1 and negatively correlated with high-density lipoprotein cholesterol (P<0.05). In multiple linear regression, asprosin was independently and positively correlated with triglyceride and HOMA-IR (P<0.05). Binary logistic regression revealed that asprosin was independently and positively correlated with the occurrence of MetS and IR, even after controlling for anthropometric variables, lipid profiles, and inflammatory markers. Conclusion. Asprosin is a potential metabolic-related adipokine and may be related to IR and MetS. This trial was registered with ChiCTR, ChiCTR1800018347. |
| format | Article |
| id | doaj-art-a9588f3353dc432ab5009cd7cfe37aa1 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-a9588f3353dc432ab5009cd7cfe37aa12025-02-03T05:49:15ZengWileyInternational Journal of Endocrinology1687-83371687-83452021-01-01202110.1155/2021/66221296622129High Serum Asprosin Levels Are Associated with Presence of Metabolic SyndromeTao Hong0Jiao-Yang Li1Ya-Di Wang2Xiao-Yan Qi3Zhe-Zhen Liao4Poonam Bhadel5Li Ran6Jing Yang7Bin Yan8Jiang-Hua Liu9Xin-Hua Xiao10Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, ChinaDepartment of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, ChinaDepartment of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, ChinaDepartment of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, ChinaDepartment of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, ChinaDepartment of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, ChinaDepartment of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, ChinaDepartment of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, ChinaDepartment of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, ChinaDepartment of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, ChinaDepartment of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, ChinaObjective. Asprosin, a new adipocytokine, has reportedly been associated with glucose release, dyslipidemia, and insulin resistance (IR). However, the relationship of asprosin with metabolic syndrome (MetS) remains unknown. This study aimed to investigate serum asprosin levels in MetS as well as their association with various metabolic parameters in humans. Methods. A total of 131 consecutive patients with MetS, and 162 age-matched, healthy subjects were recruited for this study. Serum asprosin concentrations were determined using the enzyme-linked immunosorbent assay. Lipid profile, glucose, insulin, and inflammatory markers were also measured. Results. Serum asprosin levels were higher in subjects with MetS (23.52 [16.70, 32.05] ng/mL) than in controls (16.70 [12.87, 22.38] ng/mL; P<0.01), and they showed an increasing trend with increasing numbers of metabolic components (P for trend < 0.01). In all studied subjects, serum asprosin levels were positively correlated with body mass index, waist circumference, triglycerides, fasting plasma glucose, 2-hour plasma glucose, fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR) index, interleukin-6, and monocyte chemoattractant protein-1 and negatively correlated with high-density lipoprotein cholesterol (P<0.05). In multiple linear regression, asprosin was independently and positively correlated with triglyceride and HOMA-IR (P<0.05). Binary logistic regression revealed that asprosin was independently and positively correlated with the occurrence of MetS and IR, even after controlling for anthropometric variables, lipid profiles, and inflammatory markers. Conclusion. Asprosin is a potential metabolic-related adipokine and may be related to IR and MetS. This trial was registered with ChiCTR, ChiCTR1800018347.http://dx.doi.org/10.1155/2021/6622129 |
| spellingShingle | Tao Hong Jiao-Yang Li Ya-Di Wang Xiao-Yan Qi Zhe-Zhen Liao Poonam Bhadel Li Ran Jing Yang Bin Yan Jiang-Hua Liu Xin-Hua Xiao High Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome International Journal of Endocrinology |
| title | High Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome |
| title_full | High Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome |
| title_fullStr | High Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome |
| title_full_unstemmed | High Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome |
| title_short | High Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome |
| title_sort | high serum asprosin levels are associated with presence of metabolic syndrome |
| url | http://dx.doi.org/10.1155/2021/6622129 |
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