Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's Disease
Objective. To screen the susceptibility genes in Chinese pedigrees with early-onset familial Parkinson's disease (FPD). Methods. Fifty-one genomic DNA samples extracted from two Chinese pedigrees with FPD, the alpha-synuclein genes (SNCA), the leucine-rich repeat kinase 2(LRRK2), PINK1(PTEN-in...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2010/674740 |
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| author | Changshui Xu Jun Xu Yanmin Zhang Jianjun Ma Hideshi Kawakami Hirofumi Maruyama Masaki Kamada |
| author_facet | Changshui Xu Jun Xu Yanmin Zhang Jianjun Ma Hideshi Kawakami Hirofumi Maruyama Masaki Kamada |
| author_sort | Changshui Xu |
| collection | DOAJ |
| description | Objective. To screen the susceptibility genes in Chinese pedigrees with early-onset familial Parkinson's disease (FPD). Methods. Fifty-one genomic DNA samples extracted from two Chinese pedigrees with FPD, the alpha-synuclein genes (SNCA), the leucine-rich repeat kinase 2(LRRK2), PINK1(PTEN-induced putative kinase 1), PARK7(Protein DJ1), PARK2(Parkinson juvenile disease protein 2), the glucocerebrosidase (GBA), and ATP(Ezrin-binding protein PACE-1), were sequenced by the use of polymerase chain reaction (PCR) technique. The gene dose of SNCA was checked. Results. There were only two missense mutations observed, respectively, at exon 5 of LRRK2 and exon 10 of PARK2, and both were enrolled in SNPs. Conclusion. No meaningful mutations could be detected, and other susceptibility genes should be detected in FDP patients in China. |
| format | Article |
| id | doaj-art-a94b369b025c4bb19a8b46c74034c826 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-a94b369b025c4bb19a8b46c74034c8262025-02-03T05:46:14ZengWileyNeurology Research International2090-18522090-18602010-01-01201010.1155/2010/674740674740Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's DiseaseChangshui Xu0Jun Xu1Yanmin Zhang2Jianjun Ma3Hideshi Kawakami4Hirofumi Maruyama5Masaki Kamada6Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, ChinaDepartment of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, ChinaDepartment of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, ChinaDepartment of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, ChinaDepartment of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, JapanObjective. To screen the susceptibility genes in Chinese pedigrees with early-onset familial Parkinson's disease (FPD). Methods. Fifty-one genomic DNA samples extracted from two Chinese pedigrees with FPD, the alpha-synuclein genes (SNCA), the leucine-rich repeat kinase 2(LRRK2), PINK1(PTEN-induced putative kinase 1), PARK7(Protein DJ1), PARK2(Parkinson juvenile disease protein 2), the glucocerebrosidase (GBA), and ATP(Ezrin-binding protein PACE-1), were sequenced by the use of polymerase chain reaction (PCR) technique. The gene dose of SNCA was checked. Results. There were only two missense mutations observed, respectively, at exon 5 of LRRK2 and exon 10 of PARK2, and both were enrolled in SNPs. Conclusion. No meaningful mutations could be detected, and other susceptibility genes should be detected in FDP patients in China.http://dx.doi.org/10.1155/2010/674740 |
| spellingShingle | Changshui Xu Jun Xu Yanmin Zhang Jianjun Ma Hideshi Kawakami Hirofumi Maruyama Masaki Kamada Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's Disease Neurology Research International |
| title | Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's Disease |
| title_full | Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's Disease |
| title_fullStr | Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's Disease |
| title_full_unstemmed | Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's Disease |
| title_short | Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's Disease |
| title_sort | analysis on the susceptibility genes in two chinese pedigrees with familial parkinson s disease |
| url | http://dx.doi.org/10.1155/2010/674740 |
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