Inhibition of CYP450 family 1 subfamily B member 1 (CYP1B1) expression in macrophage reduces the inflammatory response in type 2 diabetes mellitus combined with tuberculosis

Inhibition of CYP450 family 1 subfamily B member 1 (CYP1B1) expression in macrophage reduces the inflammatory response in type 2 diabetes mellitus combined with tuberculosis

Type 2 diabetes (T2DM) and tuberculosis (TB) both regulate inflammation and may exert synergistic or antagonistic effects through shared immune pathways. Previous studies have demonstrated that T2DM is a risk factor for TB. However, at the level of gene regulatory networks, it remains unclear whethe...

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Bibliographic Details
Main Authors: Qianqian Du, Kun Liu, Yanling Li, Xinyan Wang, Xin Liu, Jing Zhao, Xuemei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Endocrinology
Subjects:
tuberculosis
type 2 diabetes
macrophages
CYP1B1
inflammatory response
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1617292/full
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