Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan
Objectives This study aimed to examine the association between infertility treatment and neurodevelopment in children at 2 and 3.5 years of age.Design Prospective cohort study.Setting and participants The study population consisted of mother–child pairs who participated in the Tohoku Medical Megaban...
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e060944.full |
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| author | Mami Ishikuro Shinichi Kuriyama Shigeo Kure Junichi Sugawara Taku Obara Nobuo Yaegashi Tatsui Otsuka Aoi Noda Keiko Murakami Fumihiko Ueno Fumiko Matsuzaki Tomomi Onuma Zen Watanabe Naomi Shiga Noriyuki Iwama Hamada Hirotaka Masahito Tachibana Hiroaki Tomita Masatoshi Saito |
| author_facet | Mami Ishikuro Shinichi Kuriyama Shigeo Kure Junichi Sugawara Taku Obara Nobuo Yaegashi Tatsui Otsuka Aoi Noda Keiko Murakami Fumihiko Ueno Fumiko Matsuzaki Tomomi Onuma Zen Watanabe Naomi Shiga Noriyuki Iwama Hamada Hirotaka Masahito Tachibana Hiroaki Tomita Masatoshi Saito |
| author_sort | Mami Ishikuro |
| collection | DOAJ |
| description | Objectives This study aimed to examine the association between infertility treatment and neurodevelopment in children at 2 and 3.5 years of age.Design Prospective cohort study.Setting and participants The study population consisted of mother–child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan. Pregnant women were recruited in obstetric clinics or hospitals and their children were followed up by the questionnaire.Outcome measures The children’s neurodevelopmental outcomes were assessed at 2 and 3.5 years of age using the Ages and Stages Questionnaire, third edition (ASQ-3), which consists of questions on five developmental domains. We performed a multivariate logistic regression analysis of the association between infertility treatment (including ovulation induction (OI), artificial insemination with husband’s sperm (AIH) and assisted reproductive technology (ART)) and the clinical range of ASQ-3.Results Of 9655 mother–child pairs, 273 (2.8%) and 487 (5.0%) were conceived through OI/AIH and ART, respectively. The odds of having developmental delays at 2 years of age were higher in children conceived through OI/AIH (OR, 1.36; 95% CI 1.00 to 1.85) and ART (OR, 1.36; 95% CI 1.07 to 1.72) than in those conceived naturally. Additionally, OI/AIH and ART were significantly associated with communication (OR, 1.93; 95% CI 1.25 to 2.98) and gross motor (OR, 1.50; 95% CI 1.08 to 2.09) delays, respectively. There were no statistically significant differences in the odds of having developmental delays at 3.5 years of age in children conceived through OI/AIH (OR, 1.13; 95% CI 0.79 to 1.61) and ART (OR, 1.03; 95% CI 0.78 to 1.37).Conclusion In this study, we found a significant association between infertility treatment and children’s neurodevelopment at 2 years of age, whereas no statistically significant differences were found at 3.5 years of age. |
| format | Article |
| id | doaj-art-a93c4919322d4b04a2ac4efbd30eafe3 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-a93c4919322d4b04a2ac4efbd30eafe32025-02-01T10:40:10ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2022-060944Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, JapanMami Ishikuro0Shinichi Kuriyama1Shigeo Kure2Junichi Sugawara3Taku Obara4Nobuo Yaegashi5Tatsui Otsuka6Aoi Noda7Keiko Murakami8Fumihiko Ueno9Fumiko Matsuzaki10Tomomi Onuma11Zen Watanabe12Naomi Shiga13Noriyuki Iwama14Hamada Hirotaka15Masahito Tachibana16Hiroaki Tomita17Masatoshi Saito1811 Department of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Sendai, Japan8 Department of Disaster Public Health, International Research Institute of Disaster Science (IRIDeS), Tohoku University, Sendai, Japan9 Department of Pediatrics, Graduate School of Medicine, Tohoku University, Sendai, JapanDepartment of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Miyagi, JapanTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan12Tohoku University Graduate School of Medicine, Department of Obstetrics and Gynecology, Miyagi, JapanDepartment of Psychiatry, Tohoku University Hospital, Sendai, Miyagi, JapanTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, JapanTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, JapanTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, JapanTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, JapanTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, JapanDepartment of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Miyagi, JapanDepartment of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Miyagi, JapanTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, JapanDepartment of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Miyagi, JapanDepartment of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Miyagi, JapanTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, JapanDepartment of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Miyagi, JapanObjectives This study aimed to examine the association between infertility treatment and neurodevelopment in children at 2 and 3.5 years of age.Design Prospective cohort study.Setting and participants The study population consisted of mother–child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan. Pregnant women were recruited in obstetric clinics or hospitals and their children were followed up by the questionnaire.Outcome measures The children’s neurodevelopmental outcomes were assessed at 2 and 3.5 years of age using the Ages and Stages Questionnaire, third edition (ASQ-3), which consists of questions on five developmental domains. We performed a multivariate logistic regression analysis of the association between infertility treatment (including ovulation induction (OI), artificial insemination with husband’s sperm (AIH) and assisted reproductive technology (ART)) and the clinical range of ASQ-3.Results Of 9655 mother–child pairs, 273 (2.8%) and 487 (5.0%) were conceived through OI/AIH and ART, respectively. The odds of having developmental delays at 2 years of age were higher in children conceived through OI/AIH (OR, 1.36; 95% CI 1.00 to 1.85) and ART (OR, 1.36; 95% CI 1.07 to 1.72) than in those conceived naturally. Additionally, OI/AIH and ART were significantly associated with communication (OR, 1.93; 95% CI 1.25 to 2.98) and gross motor (OR, 1.50; 95% CI 1.08 to 2.09) delays, respectively. There were no statistically significant differences in the odds of having developmental delays at 3.5 years of age in children conceived through OI/AIH (OR, 1.13; 95% CI 0.79 to 1.61) and ART (OR, 1.03; 95% CI 0.78 to 1.37).Conclusion In this study, we found a significant association between infertility treatment and children’s neurodevelopment at 2 years of age, whereas no statistically significant differences were found at 3.5 years of age.https://bmjopen.bmj.com/content/12/6/e060944.full |
| spellingShingle | Mami Ishikuro Shinichi Kuriyama Shigeo Kure Junichi Sugawara Taku Obara Nobuo Yaegashi Tatsui Otsuka Aoi Noda Keiko Murakami Fumihiko Ueno Fumiko Matsuzaki Tomomi Onuma Zen Watanabe Naomi Shiga Noriyuki Iwama Hamada Hirotaka Masahito Tachibana Hiroaki Tomita Masatoshi Saito Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan BMJ Open |
| title | Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan |
| title_full | Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan |
| title_fullStr | Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan |
| title_full_unstemmed | Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan |
| title_short | Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan |
| title_sort | association between maternal infertility treatment and child neurodevelopment findings from the tohoku medical megabank project birth and three generation cohort study in miyagi and iwate prefectures japan |
| url | https://bmjopen.bmj.com/content/12/6/e060944.full |
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