Merkel Cell Carcinoma: The Past, the Present, and the Future
Since the first description of the Merkel cell carcinoma by Cyril Toker in 1972, the number of studies has significantly increased over the last 4 decades. In this review, we will illustrate the historical background of the Merkel cell carcinoma beginning with the 19th century, the first description...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2013/929364 |
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| _version_ | 1832567538143199232 |
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| author | Inamaria Erovic Boban M. Erovic |
| author_facet | Inamaria Erovic Boban M. Erovic |
| author_sort | Inamaria Erovic |
| collection | DOAJ |
| description | Since the first description of the Merkel cell carcinoma by Cyril Toker in 1972, the number of studies has significantly increased over the last 4 decades. In this review, we will illustrate the historical background of the Merkel cell carcinoma beginning with the 19th century, the first description of the Merkel cell to the finding of the CK20 as a highly specific diagnostic marker and finally to the recently detected Merkel cell polyomavirus (MCPyV). Moreover, we will highlight the beginning of adjuvant therapeutic regimens with radiotherapy and chemotherapy and discuss the diagnostic work-up including imaging and histology of patients with Merkel cell carcinoma. Another very rapidly growing and interesting field of research is the development of patients' specific and tailored targeted therapy, in particular in patients with distant metastatic disease. |
| format | Article |
| id | doaj-art-a92f514dc08b41258181ebbd98a7e001 |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-a92f514dc08b41258181ebbd98a7e0012025-02-03T01:01:19ZengWileyJournal of Skin Cancer2090-29052090-29132013-01-01201310.1155/2013/929364929364Merkel Cell Carcinoma: The Past, the Present, and the FutureInamaria Erovic0Boban M. Erovic1Medical University of Vienna, 1090 Vienna, AustriaMedical University of Vienna, Department of Otolaryngology, Head and Neck Surgery, 1090 Vienna, AustriaSince the first description of the Merkel cell carcinoma by Cyril Toker in 1972, the number of studies has significantly increased over the last 4 decades. In this review, we will illustrate the historical background of the Merkel cell carcinoma beginning with the 19th century, the first description of the Merkel cell to the finding of the CK20 as a highly specific diagnostic marker and finally to the recently detected Merkel cell polyomavirus (MCPyV). Moreover, we will highlight the beginning of adjuvant therapeutic regimens with radiotherapy and chemotherapy and discuss the diagnostic work-up including imaging and histology of patients with Merkel cell carcinoma. Another very rapidly growing and interesting field of research is the development of patients' specific and tailored targeted therapy, in particular in patients with distant metastatic disease.http://dx.doi.org/10.1155/2013/929364 |
| spellingShingle | Inamaria Erovic Boban M. Erovic Merkel Cell Carcinoma: The Past, the Present, and the Future Journal of Skin Cancer |
| title | Merkel Cell Carcinoma: The Past, the Present, and the Future |
| title_full | Merkel Cell Carcinoma: The Past, the Present, and the Future |
| title_fullStr | Merkel Cell Carcinoma: The Past, the Present, and the Future |
| title_full_unstemmed | Merkel Cell Carcinoma: The Past, the Present, and the Future |
| title_short | Merkel Cell Carcinoma: The Past, the Present, and the Future |
| title_sort | merkel cell carcinoma the past the present and the future |
| url | http://dx.doi.org/10.1155/2013/929364 |
| work_keys_str_mv | AT inamariaerovic merkelcellcarcinomathepastthepresentandthefuture AT bobanmerovic merkelcellcarcinomathepastthepresentandthefuture |