A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma
Abstract Liver hepatocellular carcinoma (LIHC) is a highly heterogeneous disease, necessitating the discovery of novel biomarkers to enhance individualized treatment approaches. Recent research has shown the significant involvement of ubiquitin-related genes (UbRGs) in the progression of LIHC. Howev...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01768-0 |
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| author | Xiuyun Chen SenLin Li Lixue Cao Shaoxian Chen Qiuxiong Lin Shilong Zhong |
| author_facet | Xiuyun Chen SenLin Li Lixue Cao Shaoxian Chen Qiuxiong Lin Shilong Zhong |
| author_sort | Xiuyun Chen |
| collection | DOAJ |
| description | Abstract Liver hepatocellular carcinoma (LIHC) is a highly heterogeneous disease, necessitating the discovery of novel biomarkers to enhance individualized treatment approaches. Recent research has shown the significant involvement of ubiquitin-related genes (UbRGs) in the progression of LIHC. However, the prognostic value of UbRGs in LIHC has not been investigated. In this study, the mRNA expression profiles and clinical data were obtained from public databases of LIHC patients. The least absolute shrinkage and selection operator Cox regression model was employed to construct a multigene signature in the TCGA cohort. Our results showed that a twelve UbRGs signature was developed to categorize patients into two risk groups, with significant differences in expression between LIHC and normal tissues. Patients in the high-risk group exhibited significantly reduced overall survival (OS) and progression-free survival compared to those in the low-risk group. The risk score was identified as an independent predictor for OS in multivariate Cox regression analyses. Receiver operating characteristic curve analysis confirmed the predictive capacity of the signature. Functional analysis revealed enrichment of immune-related pathways and differences in immune status between the two risk groups. The risk score was correlated with 35 transcription factors and 26 eRNA enhancers, and positively associated with tumor mutation burden. Patients in the high-risk group demonstrated decreased sensitivity to targeted and chemotherapeutic drugs than those in the low-risk group. In conclusion, our study identified a twelve UbRGs signature that may serve as a prognostic predictor for LIHC patients and and provide valuable insights for cancer treatment. |
| format | Article |
| id | doaj-art-a91a8a50a5ef4ce692668ad44ed001f4 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-a91a8a50a5ef4ce692668ad44ed001f42025-01-26T12:39:49ZengSpringerDiscover Oncology2730-60112025-01-0116111610.1007/s12672-025-01768-0A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinomaXiuyun Chen0SenLin Li1Lixue Cao2Shaoxian Chen3Qiuxiong Lin4Shilong Zhong5Medical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityMedical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityMedical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityMedical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityMedical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityMedical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityAbstract Liver hepatocellular carcinoma (LIHC) is a highly heterogeneous disease, necessitating the discovery of novel biomarkers to enhance individualized treatment approaches. Recent research has shown the significant involvement of ubiquitin-related genes (UbRGs) in the progression of LIHC. However, the prognostic value of UbRGs in LIHC has not been investigated. In this study, the mRNA expression profiles and clinical data were obtained from public databases of LIHC patients. The least absolute shrinkage and selection operator Cox regression model was employed to construct a multigene signature in the TCGA cohort. Our results showed that a twelve UbRGs signature was developed to categorize patients into two risk groups, with significant differences in expression between LIHC and normal tissues. Patients in the high-risk group exhibited significantly reduced overall survival (OS) and progression-free survival compared to those in the low-risk group. The risk score was identified as an independent predictor for OS in multivariate Cox regression analyses. Receiver operating characteristic curve analysis confirmed the predictive capacity of the signature. Functional analysis revealed enrichment of immune-related pathways and differences in immune status between the two risk groups. The risk score was correlated with 35 transcription factors and 26 eRNA enhancers, and positively associated with tumor mutation burden. Patients in the high-risk group demonstrated decreased sensitivity to targeted and chemotherapeutic drugs than those in the low-risk group. In conclusion, our study identified a twelve UbRGs signature that may serve as a prognostic predictor for LIHC patients and and provide valuable insights for cancer treatment.https://doi.org/10.1007/s12672-025-01768-0UbiquitinUbiquitin-related gene pairOverall survivalFunctional analysisLiver hepatocellular carcinoma |
| spellingShingle | Xiuyun Chen SenLin Li Lixue Cao Shaoxian Chen Qiuxiong Lin Shilong Zhong A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma Discover Oncology Ubiquitin Ubiquitin-related gene pair Overall survival Functional analysis Liver hepatocellular carcinoma |
| title | A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma |
| title_full | A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma |
| title_fullStr | A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma |
| title_full_unstemmed | A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma |
| title_short | A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma |
| title_sort | novel ubiquitination related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma |
| topic | Ubiquitin Ubiquitin-related gene pair Overall survival Functional analysis Liver hepatocellular carcinoma |
| url | https://doi.org/10.1007/s12672-025-01768-0 |
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