Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression
Prostate proliferation is dependent of androgens and many peptide hormones. Recent reports suggest that SSTR2 and SHP-1 were two fundamental components on antiproliferative effect of somatostatin. Many studies on SHP-1 revealed that the expression of this protein was diminished or abolished in sever...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2009/723831 |
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| author | Ariel Ernesto Cariaga-Martinez María Angelica Lorenzati Mario Alejandro Riera Marisa Angelica Cubilla Andrés De La Rossa Ernesto Martín Giorgio María Mercedes Tiscornia Esteban Mariano Gimenez María Eugenia Rojas Bárbara Julieta Chaneton Dora Isabel Rodríguez Pedro Darío Zapata |
| author_facet | Ariel Ernesto Cariaga-Martinez María Angelica Lorenzati Mario Alejandro Riera Marisa Angelica Cubilla Andrés De La Rossa Ernesto Martín Giorgio María Mercedes Tiscornia Esteban Mariano Gimenez María Eugenia Rojas Bárbara Julieta Chaneton Dora Isabel Rodríguez Pedro Darío Zapata |
| author_sort | Ariel Ernesto Cariaga-Martinez |
| collection | DOAJ |
| description | Prostate proliferation is dependent of androgens and many peptide hormones. Recent reports suggest that SSTR2 and SHP-1 were two fundamental components on antiproliferative effect of somatostatin. Many studies on SHP-1 revealed that the expression of this protein was diminished or abolished in several of the cancer cell lines and tissues examined. However, it is necessary to confront the cell lines data with real situation in cancer cases. Our studies have shown that epithelial expressions of both proteins, SHP-1 and SSTR2, in normal and benign hyperplasia are localized in the luminal side of duct and acinar cells. Also, SSTR2 is expressed in stromal cells. In malignant prostate tissue, SHP-1 was diminished in 28/45 cases or absent in 12/45 cases, whereas SSTR2 epithelial was diminished in 38/45 cases or lost in only 2/45 cases. The intensity of immunostained was highly negative correlated with Gleason grade for two proteins. |
| format | Article |
| id | doaj-art-a90cb73409284d58bc1919fe52bb9365 |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-a90cb73409284d58bc1919fe52bb93652025-02-03T01:02:36ZengWileyAdvances in Urology1687-63691687-63772009-01-01200910.1155/2009/723831723831Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor ProgressionAriel Ernesto Cariaga-Martinez0María Angelica Lorenzati1Mario Alejandro Riera2Marisa Angelica Cubilla3Andrés De La Rossa4Ernesto Martín Giorgio5María Mercedes Tiscornia6Esteban Mariano Gimenez7María Eugenia Rojas8Bárbara Julieta Chaneton9Dora Isabel Rodríguez10Pedro Darío Zapata11Laboratorio de Biologia Molecular, Facultad de Ciencias Exactas Aplicada Químicas y Naturales, Universidad Nacional de Misiones, N3300LQH Posadas, ArgentinaLaboratorio de Biologia Molecular, Facultad de Ciencias Exactas Aplicada Químicas y Naturales, Universidad Nacional de Misiones, N3300LQH Posadas, ArgentinaLaboratorio de Biologia Molecular, Facultad de Ciencias Exactas Aplicada Químicas y Naturales, Universidad Nacional de Misiones, N3300LQH Posadas, ArgentinaLaboratorio de Biologia Molecular, Facultad de Ciencias Exactas Aplicada Químicas y Naturales, Universidad Nacional de Misiones, N3300LQH Posadas, ArgentinaLaboratorio de Biologia Molecular, Facultad de Ciencias Exactas Aplicada Químicas y Naturales, Universidad Nacional de Misiones, N3300LQH Posadas, ArgentinaLaboratorio de Biologia Molecular, Facultad de Ciencias Exactas Aplicada Químicas y Naturales, Universidad Nacional de Misiones, N3300LQH Posadas, ArgentinaLaboratorio de Biologia Molecular, Facultad de Ciencias Exactas Aplicada Químicas y Naturales, Universidad Nacional de Misiones, N3300LQH Posadas, ArgentinaLaboratorio de Biologia Molecular, Facultad de Ciencias Exactas Aplicada Químicas y Naturales, Universidad Nacional de Misiones, N3300LQH Posadas, ArgentinaLaboratorio de Biologia Molecular, Facultad de Ciencias Exactas Aplicada Químicas y Naturales, Universidad Nacional de Misiones, N3300LQH Posadas, ArgentinaLaboratorio de Biologia Molecular, Facultad de Ciencias Exactas Aplicada Químicas y Naturales, Universidad Nacional de Misiones, N3300LQH Posadas, ArgentinaLaboratorio de Biologia Molecular, Facultad de Ciencias Exactas Aplicada Químicas y Naturales, Universidad Nacional de Misiones, N3300LQH Posadas, ArgentinaLaboratorio de Biologia Molecular, Facultad de Ciencias Exactas Aplicada Químicas y Naturales, Universidad Nacional de Misiones, N3300LQH Posadas, ArgentinaProstate proliferation is dependent of androgens and many peptide hormones. Recent reports suggest that SSTR2 and SHP-1 were two fundamental components on antiproliferative effect of somatostatin. Many studies on SHP-1 revealed that the expression of this protein was diminished or abolished in several of the cancer cell lines and tissues examined. However, it is necessary to confront the cell lines data with real situation in cancer cases. Our studies have shown that epithelial expressions of both proteins, SHP-1 and SSTR2, in normal and benign hyperplasia are localized in the luminal side of duct and acinar cells. Also, SSTR2 is expressed in stromal cells. In malignant prostate tissue, SHP-1 was diminished in 28/45 cases or absent in 12/45 cases, whereas SSTR2 epithelial was diminished in 38/45 cases or lost in only 2/45 cases. The intensity of immunostained was highly negative correlated with Gleason grade for two proteins.http://dx.doi.org/10.1155/2009/723831 |
| spellingShingle | Ariel Ernesto Cariaga-Martinez María Angelica Lorenzati Mario Alejandro Riera Marisa Angelica Cubilla Andrés De La Rossa Ernesto Martín Giorgio María Mercedes Tiscornia Esteban Mariano Gimenez María Eugenia Rojas Bárbara Julieta Chaneton Dora Isabel Rodríguez Pedro Darío Zapata Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression Advances in Urology |
| title | Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression |
| title_full | Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression |
| title_fullStr | Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression |
| title_full_unstemmed | Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression |
| title_short | Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression |
| title_sort | tumoral prostate shows different expression pattern of somatostatin receptor 2 sstr2 and phosphotyrosine phosphatase shp 1 ptpn6 according to tumor progression |
| url | http://dx.doi.org/10.1155/2009/723831 |
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