Addressing genome scale design tradeoffs in Pseudomonas putida for bioconversion of an aromatic carbon source
Abstract Genome-scale metabolic models (GSMM) are commonly used to identify gene deletion sets that result in growth coupling and pairing product formation with substrate utilization and can improve strain performance beyond levels typically accessible using traditional strain engineering approaches...
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Main Authors: | Deepanwita Banerjee, Javier Menasalvas, Yan Chen, Jennifer W. Gin, Edward E. K. Baidoo, Christopher J. Petzold, Thomas Eng, Aindrila Mukhopadhyay |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2025-01-01
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Series: | npj Systems Biology and Applications |
Online Access: | https://doi.org/10.1038/s41540-024-00480-z |
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