Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats
Dihydromyricetin (DHM), as a bioactive flavanonol compound, is mainly found in “Tengcha” (Ampelopsis grossedentata) cultivated in south of China. This study aimed to investigate the anti-hyperglycemic and anti-dyslipidemic activities of DHM using type 2 diabetes mellitus (T2D) rats, which was induce...
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Tsinghua University Press
2021-03-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000124 |
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| author | Maojun Yao Hui Teng Qiyan Lv Huifang Gao Tengming Guo Yiwen Lin Sihai Gao Meihu Ma Lei Chen |
| author_facet | Maojun Yao Hui Teng Qiyan Lv Huifang Gao Tengming Guo Yiwen Lin Sihai Gao Meihu Ma Lei Chen |
| author_sort | Maojun Yao |
| collection | DOAJ |
| description | Dihydromyricetin (DHM), as a bioactive flavanonol compound, is mainly found in “Tengcha” (Ampelopsis grossedentata) cultivated in south of China. This study aimed to investigate the anti-hyperglycemic and anti-dyslipidemic activities of DHM using type 2 diabetes mellitus (T2D) rats, which was induced by feeding with high fat and fructose diet for 42 days and intraperitoneal administration of streptozocin. Forty-eight freshly-weaned rats were randomly assigned into the negative control (Blank), low dose (100 mg/kg), medium dose (200 mg/kg), high dose (400 mg/kg), and positive (40 mg/kg, met) groups. Fasting blood glucose and body weight were measured at weekly interval. Oral glucose tolerance tests were performed on days 42. The results revealed that DHM possessed significant antihyperglycaemic and antihyperinsulinemic effects. Moreover, after the DHM treatment, p-Akt and p-AMPK expression was upregulated, and glycogen synthase kinase-3β (GSK-3β) expression was downregulated, indicating that the potential anti-diabetic mechanism of DHM might be due to the regulation of the AMPK/Akt/GSK-3β signaling pathway. |
| format | Article |
| id | doaj-art-a9060bb0b710409298d26eeece56ee20 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-a9060bb0b710409298d26eeece56ee202025-02-03T04:06:59ZengTsinghua University PressFood Science and Human Wellness2213-45302021-03-01102155162Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic ratsMaojun Yao0Hui Teng1Qiyan Lv2Huifang Gao3Tengming Guo4Yiwen Lin5Sihai Gao6Meihu Ma7Lei Chen8College of Chemistry and Chemical Engineering, Jishou University, Jishou, 416000, China; National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China; College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524025, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, ChinaDepartment of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China; Corresponding authors.National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China; Corresponding authors.College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China; College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524025, China; Corresponding authors.Dihydromyricetin (DHM), as a bioactive flavanonol compound, is mainly found in “Tengcha” (Ampelopsis grossedentata) cultivated in south of China. This study aimed to investigate the anti-hyperglycemic and anti-dyslipidemic activities of DHM using type 2 diabetes mellitus (T2D) rats, which was induced by feeding with high fat and fructose diet for 42 days and intraperitoneal administration of streptozocin. Forty-eight freshly-weaned rats were randomly assigned into the negative control (Blank), low dose (100 mg/kg), medium dose (200 mg/kg), high dose (400 mg/kg), and positive (40 mg/kg, met) groups. Fasting blood glucose and body weight were measured at weekly interval. Oral glucose tolerance tests were performed on days 42. The results revealed that DHM possessed significant antihyperglycaemic and antihyperinsulinemic effects. Moreover, after the DHM treatment, p-Akt and p-AMPK expression was upregulated, and glycogen synthase kinase-3β (GSK-3β) expression was downregulated, indicating that the potential anti-diabetic mechanism of DHM might be due to the regulation of the AMPK/Akt/GSK-3β signaling pathway.http://www.sciencedirect.com/science/article/pii/S2213453021000124Dihydromyricetintype 2 diabeteshypolipidemichypoglycemicAMPK/Akt/GSK-3β signaling pathway |
| spellingShingle | Maojun Yao Hui Teng Qiyan Lv Huifang Gao Tengming Guo Yiwen Lin Sihai Gao Meihu Ma Lei Chen Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats Food Science and Human Wellness Dihydromyricetin type 2 diabetes hypolipidemic hypoglycemic AMPK/Akt/GSK-3β signaling pathway |
| title | Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats |
| title_full | Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats |
| title_fullStr | Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats |
| title_full_unstemmed | Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats |
| title_short | Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats |
| title_sort | anti hyperglycemic effects of dihydromyricetin in streptozotocin induced diabetic rats |
| topic | Dihydromyricetin type 2 diabetes hypolipidemic hypoglycemic AMPK/Akt/GSK-3β signaling pathway |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000124 |
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