Gastrointestinal Dysfunctions Are Associated with IL-10 Variants in Parkinson’s Disease
Inflammation has been demonstrated to be involved in Parkinson’s disease (PD) pathogenesis. There were evidences that the disturbance of the protective function of IL-10 gene contributed to PD. In our study, haplotype analyses were conducted of IL-10 rs1800871 and rs1800872 on 371 PD patients. Becau...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2018/5908359 |
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| author | Li Shu Dongxiao Liang Hongxu Pan Qian Xu Xinxiang Yan Beisha Tang Qiying Sun |
| author_facet | Li Shu Dongxiao Liang Hongxu Pan Qian Xu Xinxiang Yan Beisha Tang Qiying Sun |
| author_sort | Li Shu |
| collection | DOAJ |
| description | Inflammation has been demonstrated to be involved in Parkinson’s disease (PD) pathogenesis. There were evidences that the disturbance of the protective function of IL-10 gene contributed to PD. In our study, haplotype analyses were conducted of IL-10 rs1800871 and rs1800872 on 371 PD patients. Because the two SNPs exposed significant linkage disequilibrium demonstrated by Haploview software, we included 177 carriers of both rs1800871 and rs1800872 and 190 noncarriers in clinical phenotype analyses. As to nonmotor symptoms, the score of the gastrointestinal dysfunction domain in Nonmotor Symptom Scale (NMSS) was lower in the carrier group of both SNPs than in the noncarrier group in PD patients (SC: −0.198, p:0.023). Other nonmotor symptoms reflected by relevant rating scales showed negative results. As to comorbidity, no significant statistical significance was observed between the two SNPs and Charlson Comorbidity Index (CCI). In conclusion, we found less severe gastrointestinal dysfunctions of both IL-10 rs1800871 and rs1800872 carriers than noncarriers in PD. |
| format | Article |
| id | doaj-art-a8fe3718cab4401e8e3514d076575c52 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-a8fe3718cab4401e8e3514d076575c522025-02-03T06:00:01ZengWileyParkinson's Disease2090-80832042-00802018-01-01201810.1155/2018/59083595908359Gastrointestinal Dysfunctions Are Associated with IL-10 Variants in Parkinson’s DiseaseLi Shu0Dongxiao Liang1Hongxu Pan2Qian Xu3Xinxiang Yan4Beisha Tang5Qiying Sun6Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, Hunan 410078, ChinaInflammation has been demonstrated to be involved in Parkinson’s disease (PD) pathogenesis. There were evidences that the disturbance of the protective function of IL-10 gene contributed to PD. In our study, haplotype analyses were conducted of IL-10 rs1800871 and rs1800872 on 371 PD patients. Because the two SNPs exposed significant linkage disequilibrium demonstrated by Haploview software, we included 177 carriers of both rs1800871 and rs1800872 and 190 noncarriers in clinical phenotype analyses. As to nonmotor symptoms, the score of the gastrointestinal dysfunction domain in Nonmotor Symptom Scale (NMSS) was lower in the carrier group of both SNPs than in the noncarrier group in PD patients (SC: −0.198, p:0.023). Other nonmotor symptoms reflected by relevant rating scales showed negative results. As to comorbidity, no significant statistical significance was observed between the two SNPs and Charlson Comorbidity Index (CCI). In conclusion, we found less severe gastrointestinal dysfunctions of both IL-10 rs1800871 and rs1800872 carriers than noncarriers in PD.http://dx.doi.org/10.1155/2018/5908359 |
| spellingShingle | Li Shu Dongxiao Liang Hongxu Pan Qian Xu Xinxiang Yan Beisha Tang Qiying Sun Gastrointestinal Dysfunctions Are Associated with IL-10 Variants in Parkinson’s Disease Parkinson's Disease |
| title | Gastrointestinal Dysfunctions Are Associated with IL-10 Variants in Parkinson’s Disease |
| title_full | Gastrointestinal Dysfunctions Are Associated with IL-10 Variants in Parkinson’s Disease |
| title_fullStr | Gastrointestinal Dysfunctions Are Associated with IL-10 Variants in Parkinson’s Disease |
| title_full_unstemmed | Gastrointestinal Dysfunctions Are Associated with IL-10 Variants in Parkinson’s Disease |
| title_short | Gastrointestinal Dysfunctions Are Associated with IL-10 Variants in Parkinson’s Disease |
| title_sort | gastrointestinal dysfunctions are associated with il 10 variants in parkinson s disease |
| url | http://dx.doi.org/10.1155/2018/5908359 |
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