<i>MTHFR</i> Gene Polymorphisms and Cancer Risk in Children and Adolescents: A Systematic Review and Meta-Analysis
<b>Background/Objectives:</b> <i>MTHFR</i> gene polymorphisms (677C>T and 1298A>C) correlate with various types of cancer across all age groups; however, a small number of studies have included solely children and adolescents. The aim of this systematic review and meta-...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Children |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9067/12/1/108 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588789305835520 |
|---|---|
| author | Savvas Kolanis Eleni P. Kotanidou Vasiliki Rengina Tsinopoulou Elisavet Georgiou Emmanuel Hatzipantelis Liana Fidani Assimina Galli-Tsinopoulou |
| author_facet | Savvas Kolanis Eleni P. Kotanidou Vasiliki Rengina Tsinopoulou Elisavet Georgiou Emmanuel Hatzipantelis Liana Fidani Assimina Galli-Tsinopoulou |
| author_sort | Savvas Kolanis |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> <i>MTHFR</i> gene polymorphisms (677C>T and 1298A>C) correlate with various types of cancer across all age groups; however, a small number of studies have included solely children and adolescents. The aim of this systematic review and meta-analysis was to present and synthesize all the available evidence on the association between <i>MTHFR</i> gene polymorphisms and the incidence of all types of cancer in children and adolescences. <b>Methods:</b> After a systematic search of all of the available data, original case–control studies involving children or adolescents with a confirmed diagnosis of any type of cancer and a molecular genetic test of <i>MTHFR</i> gene polymorphisms were included. <b>Results:</b> A total of 53 original studies in children and adolescents with cancer were included in the systematic review. Among these, 40 studies reviewed children and adolescents with Acute Lymphoblastic Leukemia (ALL), 4 those with Acute Myeloblastic Leukemia (AML), 8 those with central nervous system (CNS) tumors and 3 those with other types of cancer. Children and adolescents with ALL had less frequent T allele sequences (CT and TT variations) of the 677C>T polymorphism compared to a healthy population (OR: 0.85; CI: 0.80–0.91; <i>p</i> < 0.00001). Concerning the 1298A>C polymorphism, the C allele sequences (AC and CC) did not present a statistically significant difference in frequency compared to a healthy population (OR: 1.01; CI: 0.95–1.08; <i>p</i> = 0.69). <b>Conclusions:</b> Children and adolescents with ALL appeared to have the T allele sequences of the 677C>T polymorphism of the <i>MTHFR</i> gene less frequently compared to a healthy population. |
| format | Article |
| id | doaj-art-a8ef78fd651043b3b27fedb457858882 |
| institution | Kabale University |
| issn | 2227-9067 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj-art-a8ef78fd651043b3b27fedb4578588822025-01-24T13:27:20ZengMDPI AGChildren2227-90672025-01-0112110810.3390/children12010108<i>MTHFR</i> Gene Polymorphisms and Cancer Risk in Children and Adolescents: A Systematic Review and Meta-AnalysisSavvas Kolanis0Eleni P. Kotanidou1Vasiliki Rengina Tsinopoulou2Elisavet Georgiou3Emmanuel Hatzipantelis4Liana Fidani5Assimina Galli-Tsinopoulou62nd Department of Paediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece2nd Department of Paediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece2nd Department of Paediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, GreeceLaboratory of Biological Chemistry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece2nd Department of Paediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece2nd Department of Paediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece2nd Department of Paediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece<b>Background/Objectives:</b> <i>MTHFR</i> gene polymorphisms (677C>T and 1298A>C) correlate with various types of cancer across all age groups; however, a small number of studies have included solely children and adolescents. The aim of this systematic review and meta-analysis was to present and synthesize all the available evidence on the association between <i>MTHFR</i> gene polymorphisms and the incidence of all types of cancer in children and adolescences. <b>Methods:</b> After a systematic search of all of the available data, original case–control studies involving children or adolescents with a confirmed diagnosis of any type of cancer and a molecular genetic test of <i>MTHFR</i> gene polymorphisms were included. <b>Results:</b> A total of 53 original studies in children and adolescents with cancer were included in the systematic review. Among these, 40 studies reviewed children and adolescents with Acute Lymphoblastic Leukemia (ALL), 4 those with Acute Myeloblastic Leukemia (AML), 8 those with central nervous system (CNS) tumors and 3 those with other types of cancer. Children and adolescents with ALL had less frequent T allele sequences (CT and TT variations) of the 677C>T polymorphism compared to a healthy population (OR: 0.85; CI: 0.80–0.91; <i>p</i> < 0.00001). Concerning the 1298A>C polymorphism, the C allele sequences (AC and CC) did not present a statistically significant difference in frequency compared to a healthy population (OR: 1.01; CI: 0.95–1.08; <i>p</i> = 0.69). <b>Conclusions:</b> Children and adolescents with ALL appeared to have the T allele sequences of the 677C>T polymorphism of the <i>MTHFR</i> gene less frequently compared to a healthy population.https://www.mdpi.com/2227-9067/12/1/108<i>MTHFR</i> genemethylenetetrahydrofolate reductasesingle-nucleotide polymorphismcancerneoplasmsleukemia |
| spellingShingle | Savvas Kolanis Eleni P. Kotanidou Vasiliki Rengina Tsinopoulou Elisavet Georgiou Emmanuel Hatzipantelis Liana Fidani Assimina Galli-Tsinopoulou <i>MTHFR</i> Gene Polymorphisms and Cancer Risk in Children and Adolescents: A Systematic Review and Meta-Analysis Children <i>MTHFR</i> gene methylenetetrahydrofolate reductase single-nucleotide polymorphism cancer neoplasms leukemia |
| title | <i>MTHFR</i> Gene Polymorphisms and Cancer Risk in Children and Adolescents: A Systematic Review and Meta-Analysis |
| title_full | <i>MTHFR</i> Gene Polymorphisms and Cancer Risk in Children and Adolescents: A Systematic Review and Meta-Analysis |
| title_fullStr | <i>MTHFR</i> Gene Polymorphisms and Cancer Risk in Children and Adolescents: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | <i>MTHFR</i> Gene Polymorphisms and Cancer Risk in Children and Adolescents: A Systematic Review and Meta-Analysis |
| title_short | <i>MTHFR</i> Gene Polymorphisms and Cancer Risk in Children and Adolescents: A Systematic Review and Meta-Analysis |
| title_sort | i mthfr i gene polymorphisms and cancer risk in children and adolescents a systematic review and meta analysis |
| topic | <i>MTHFR</i> gene methylenetetrahydrofolate reductase single-nucleotide polymorphism cancer neoplasms leukemia |
| url | https://www.mdpi.com/2227-9067/12/1/108 |
| work_keys_str_mv | AT savvaskolanis imthfrigenepolymorphismsandcancerriskinchildrenandadolescentsasystematicreviewandmetaanalysis AT elenipkotanidou imthfrigenepolymorphismsandcancerriskinchildrenandadolescentsasystematicreviewandmetaanalysis AT vasilikirenginatsinopoulou imthfrigenepolymorphismsandcancerriskinchildrenandadolescentsasystematicreviewandmetaanalysis AT elisavetgeorgiou imthfrigenepolymorphismsandcancerriskinchildrenandadolescentsasystematicreviewandmetaanalysis AT emmanuelhatzipantelis imthfrigenepolymorphismsandcancerriskinchildrenandadolescentsasystematicreviewandmetaanalysis AT lianafidani imthfrigenepolymorphismsandcancerriskinchildrenandadolescentsasystematicreviewandmetaanalysis AT assiminagallitsinopoulou imthfrigenepolymorphismsandcancerriskinchildrenandadolescentsasystematicreviewandmetaanalysis |