Multifocal Metastatic Breast Carcinoma to the Thyroid Gland Histologically Mimicking C Cell Lesions
The thyroid gland is an uncommon site of metastatic disease. Renal cell carcinoma is the most common primary source, while metastasis from breast carcinoma is very rare. However, given that thyroid nodules are more common in women, and women with a history of breast cancer are at higher risk of deve...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2019/9890716 |
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| author | Adeeba F. Ghias Gregory Epps Elizabeth Cottrill Stacey K. Mardekian |
| author_facet | Adeeba F. Ghias Gregory Epps Elizabeth Cottrill Stacey K. Mardekian |
| author_sort | Adeeba F. Ghias |
| collection | DOAJ |
| description | The thyroid gland is an uncommon site of metastatic disease. Renal cell carcinoma is the most common primary source, while metastasis from breast carcinoma is very rare. However, given that thyroid nodules are more common in women, and women with a history of breast cancer are at higher risk of developing thyroid cancer, the possibility of metastatic breast carcinoma must be considered when evaluating a thyroid nodule. We present the case of a 67-year-old woman who presented with dysphonia and dysphagia secondary to multinodular goiter and was found to have multifocal metastatic breast carcinoma in her surgical resection specimen. The histologic appearance focally mimicked C cell hyperplasia and medullary thyroid carcinoma, so immunohistochemistry was critical for establishing the diagnosis. Metastasis to the thyroid should always be included in the differential diagnosis for a thyroid nodule in a patient with a history of previous malignancy. |
| format | Article |
| id | doaj-art-a8e96be804d340f0b7372773a2ca7cd1 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-a8e96be804d340f0b7372773a2ca7cd12025-02-03T01:02:16ZengWileyCase Reports in Pathology2090-67812090-679X2019-01-01201910.1155/2019/98907169890716Multifocal Metastatic Breast Carcinoma to the Thyroid Gland Histologically Mimicking C Cell LesionsAdeeba F. Ghias0Gregory Epps1Elizabeth Cottrill2Stacey K. Mardekian3Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USAThe thyroid gland is an uncommon site of metastatic disease. Renal cell carcinoma is the most common primary source, while metastasis from breast carcinoma is very rare. However, given that thyroid nodules are more common in women, and women with a history of breast cancer are at higher risk of developing thyroid cancer, the possibility of metastatic breast carcinoma must be considered when evaluating a thyroid nodule. We present the case of a 67-year-old woman who presented with dysphonia and dysphagia secondary to multinodular goiter and was found to have multifocal metastatic breast carcinoma in her surgical resection specimen. The histologic appearance focally mimicked C cell hyperplasia and medullary thyroid carcinoma, so immunohistochemistry was critical for establishing the diagnosis. Metastasis to the thyroid should always be included in the differential diagnosis for a thyroid nodule in a patient with a history of previous malignancy.http://dx.doi.org/10.1155/2019/9890716 |
| spellingShingle | Adeeba F. Ghias Gregory Epps Elizabeth Cottrill Stacey K. Mardekian Multifocal Metastatic Breast Carcinoma to the Thyroid Gland Histologically Mimicking C Cell Lesions Case Reports in Pathology |
| title | Multifocal Metastatic Breast Carcinoma to the Thyroid Gland Histologically Mimicking C Cell Lesions |
| title_full | Multifocal Metastatic Breast Carcinoma to the Thyroid Gland Histologically Mimicking C Cell Lesions |
| title_fullStr | Multifocal Metastatic Breast Carcinoma to the Thyroid Gland Histologically Mimicking C Cell Lesions |
| title_full_unstemmed | Multifocal Metastatic Breast Carcinoma to the Thyroid Gland Histologically Mimicking C Cell Lesions |
| title_short | Multifocal Metastatic Breast Carcinoma to the Thyroid Gland Histologically Mimicking C Cell Lesions |
| title_sort | multifocal metastatic breast carcinoma to the thyroid gland histologically mimicking c cell lesions |
| url | http://dx.doi.org/10.1155/2019/9890716 |
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