The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives
Intervertebral disc degeneration (IVDD) is a leading cause of chronic back pain, contributing significantly to reduced quality of life and global public health burdens. The TRIM (Tripartite Motif-containing) protein family, with its diverse regulatory roles, has emerged as a key player in critical c...
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| Format: | Article |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1525073/full |
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| author | Shangze Li Wenli Jiang Fei Chen Jiao Qian Jun Yang |
| author_facet | Shangze Li Wenli Jiang Fei Chen Jiao Qian Jun Yang |
| author_sort | Shangze Li |
| collection | DOAJ |
| description | Intervertebral disc degeneration (IVDD) is a leading cause of chronic back pain, contributing significantly to reduced quality of life and global public health burdens. The TRIM (Tripartite Motif-containing) protein family, with its diverse regulatory roles, has emerged as a key player in critical cellular processes such as inflammation, cell death, and extracellular matrix (ECM) metabolism. Recent findings underscore the involvement of TRIM proteins in IVDD pathogenesis, where they regulate stress responses, maintain cellular homeostasis, and influence the functional integrity of nucleus pulposus (NP) and annulus fibrosus (AF) cells. This review explores the multifaceted roles of TRIM proteins in IVDD, highlighting their contributions to pathological pathways and their potential as therapeutic targets. Advancing our understanding of TRIM protein-mediated mechanisms may pave the way for innovative and precise therapeutic strategies to combat IVDD. |
| format | Article |
| id | doaj-art-a8e7c69c37824e27a06e96c4705a226b |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-a8e7c69c37824e27a06e96c4705a226b2025-02-06T07:09:11ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-02-011310.3389/fcell.2025.15250731525073The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectivesShangze Li0Wenli Jiang1Fei Chen2Jiao Qian3Jun Yang4Department of Orthopedics, The Second Affiliated Hospital (Shanghai Changzheng Hospital), Naval Medical University, Shanghai, ChinaDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Naval Medical University, Shanghai, ChinaDepartment of Orthopedics, The Second Affiliated Hospital (Shanghai Changzheng Hospital), Naval Medical University, Shanghai, ChinaDepartment of Pharmacy, The First Affiliated Hospital (Shanghai Changhai Hospital), Naval Medical University, Shanghai, ChinaDepartment of Orthopedics, The Second Affiliated Hospital (Shanghai Changzheng Hospital), Naval Medical University, Shanghai, ChinaIntervertebral disc degeneration (IVDD) is a leading cause of chronic back pain, contributing significantly to reduced quality of life and global public health burdens. The TRIM (Tripartite Motif-containing) protein family, with its diverse regulatory roles, has emerged as a key player in critical cellular processes such as inflammation, cell death, and extracellular matrix (ECM) metabolism. Recent findings underscore the involvement of TRIM proteins in IVDD pathogenesis, where they regulate stress responses, maintain cellular homeostasis, and influence the functional integrity of nucleus pulposus (NP) and annulus fibrosus (AF) cells. This review explores the multifaceted roles of TRIM proteins in IVDD, highlighting their contributions to pathological pathways and their potential as therapeutic targets. Advancing our understanding of TRIM protein-mediated mechanisms may pave the way for innovative and precise therapeutic strategies to combat IVDD.https://www.frontiersin.org/articles/10.3389/fcell.2025.1525073/fullintervertebral disc degeneration (IVDD)TRIM protein familycell deathinflammationextracellular matrix metabolism |
| spellingShingle | Shangze Li Wenli Jiang Fei Chen Jiao Qian Jun Yang The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives Frontiers in Cell and Developmental Biology intervertebral disc degeneration (IVDD) TRIM protein family cell death inflammation extracellular matrix metabolism |
| title | The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives |
| title_full | The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives |
| title_fullStr | The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives |
| title_full_unstemmed | The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives |
| title_short | The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives |
| title_sort | critical role of trim protein family in intervertebral disc degeneration mechanistic insights and therapeutic perspectives |
| topic | intervertebral disc degeneration (IVDD) TRIM protein family cell death inflammation extracellular matrix metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1525073/full |
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