Elevated plasma levels of alpha-synuclein are dispensable for Parkinson’s disease pathology
Abstract Although α-synuclein levels are elevated in the blood plasma of Parkinson’s disease (PD) patients, it remains unclear whether blood-derived α-synuclein directly contributes to PD. To investigate this, we developed a novel mouse model in which human α-synuclein levels are increased in the bl...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01091-z |
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| Summary: | Abstract Although α-synuclein levels are elevated in the blood plasma of Parkinson’s disease (PD) patients, it remains unclear whether blood-derived α-synuclein directly contributes to PD. To investigate this, we developed a novel mouse model in which human α-synuclein levels are increased in the blood. Despite a significant increase in α-synuclein in the blood, no noticeable behavioral abnormalities were observed in aged mice. Additionally, we did not observe plasma α-synuclein aggregation in the blood or entry of human α-synuclein into the brain. These results suggest that elevated blood levels of α-synuclein may not be sufficient to induce PD progression. |
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| ISSN: | 2373-8057 |