Advanced Glycation End-Products and Hyperglycemia Increase Angiopoietin-2 Production by Impairing Angiopoietin-1-Tie-2 System
The angiopoietin-Tie-2 system plays a crucial role in the maintenance of endothelial integrity. Hyperglycemia and advanced glycation end-products (AGEs) are involved in endothelial cell dysfunction responsible of the pathogenesis of microvascular complications of diabetes. Here, we investigated whet...
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Main Authors: | Alessandra Puddu, Roberta Sanguineti, Davide Maggi, Massimo Nicolò, Carlo E. Traverso, Renzo Cordera, Giorgio L. Viviani |
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Format: | Article |
Language: | English |
Published: |
Wiley
2019-01-01
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Series: | Journal of Diabetes Research |
Online Access: | http://dx.doi.org/10.1155/2019/6198495 |
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