Latent Toxoplasmosis among Breast Cancer Patients in Jahrom, South of Iran
Objective. Reactivation of latent toxoplasmosis is the main cause of severe infection among immunocompromised patients, including patients with cancer. Hence, this study is aimed at screening the status of Toxoplasma gondii infection among breast cancer patients by serological and molecular methods...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2023/4792260 |
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| _version_ | 1832559714209103872 |
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| author | Marzeieh Haghbin Salar Maani Mohammad Aref Bagherzadeh Ahmadreza Bazmjoo Heshmatollah Shakeri Ali Taghipour Shahab Falahi Azra Kenarkoohi Milad Badri Amir Abdoli |
| author_facet | Marzeieh Haghbin Salar Maani Mohammad Aref Bagherzadeh Ahmadreza Bazmjoo Heshmatollah Shakeri Ali Taghipour Shahab Falahi Azra Kenarkoohi Milad Badri Amir Abdoli |
| author_sort | Marzeieh Haghbin |
| collection | DOAJ |
| description | Objective. Reactivation of latent toxoplasmosis is the main cause of severe infection among immunocompromised patients, including patients with cancer. Hence, this study is aimed at screening the status of Toxoplasma gondii infection among breast cancer patients by serological and molecular methods and determining their associated risk factors in Jahrom County, Fars Province, south of Iran. Methods. One hundred and seven women with breast cancer (aged 34 to 80 years) were screened for anti-T. gondii antibodies (IgG and IgM) during 2019–2020. A questionnaire regarding demographic factors was filled out by participants. Molecular detection was performed by polymerase chain reaction (PCR) using the primer pair targeting the repetitive element (RE) gene of T. gondii. The risk factors and demographic data were analyzed by SPSS software (ver. 20, Chicago, IL, USA) using the Chi-squared test. Results. Anti-T. gondii IgG was detected in 45.8% (49/107) of the patients, which indicates latent infection, but anti-T. gondii IgM and PCR were negative in all samples. Demographic factors revealed a statistically significant increased T. gondii seropositivity among nonmenopause cancer patients (P<0.0005), patients without previous breast cancer (P=0.0001), and human epidermal growth factor receptor 2- (HER2-) negative patients (P=0.00002). As such, patients with a history of previous abortions and who were at stages II, III, and IIII of cancer had higher seropositivity rates than patients without a history of previous abortions or who were at stage I cancer, but the statistical analysis was not significant. We did not find a statistically significant association between T. gondii seropositivity and other risk factors of toxoplasmosis (e.g., education level, type of water source, washing raw fruits and vegetables, consumption of raw or undercooked meat, and contact with soil, cats, and domestic animal). Conclusion. A high seroprevalence rate of latent T. gondii infection was detected among patients with breast cancer; hence, these patients may be at high risk for reactivation of latent infection. Screening of T. gondii infection is recommended to detect active infection among patients with malignancies. |
| format | Article |
| id | doaj-art-a8d09df4866c4363a913c67144300fb9 |
| institution | Kabale University |
| issn | 2090-3189 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-a8d09df4866c4363a913c67144300fb92025-02-03T01:29:28ZengWileyInternational Journal of Breast Cancer2090-31892023-01-01202310.1155/2023/4792260Latent Toxoplasmosis among Breast Cancer Patients in Jahrom, South of IranMarzeieh Haghbin0Salar Maani1Mohammad Aref Bagherzadeh2Ahmadreza Bazmjoo3Heshmatollah Shakeri4Ali Taghipour5Shahab Falahi6Azra Kenarkoohi7Milad Badri8Amir Abdoli9Research Center for Noncommunicable DiseasesStudent Research CommitteeStudent Research CommitteeStudent Research CommitteeZoonoses Research CenterZoonoses Research CenterZoonotic Diseases Research CenterDepartment of MicrobiologyMetabolic Diseases Research CenterZoonoses Research CenterObjective. Reactivation of latent toxoplasmosis is the main cause of severe infection among immunocompromised patients, including patients with cancer. Hence, this study is aimed at screening the status of Toxoplasma gondii infection among breast cancer patients by serological and molecular methods and determining their associated risk factors in Jahrom County, Fars Province, south of Iran. Methods. One hundred and seven women with breast cancer (aged 34 to 80 years) were screened for anti-T. gondii antibodies (IgG and IgM) during 2019–2020. A questionnaire regarding demographic factors was filled out by participants. Molecular detection was performed by polymerase chain reaction (PCR) using the primer pair targeting the repetitive element (RE) gene of T. gondii. The risk factors and demographic data were analyzed by SPSS software (ver. 20, Chicago, IL, USA) using the Chi-squared test. Results. Anti-T. gondii IgG was detected in 45.8% (49/107) of the patients, which indicates latent infection, but anti-T. gondii IgM and PCR were negative in all samples. Demographic factors revealed a statistically significant increased T. gondii seropositivity among nonmenopause cancer patients (P<0.0005), patients without previous breast cancer (P=0.0001), and human epidermal growth factor receptor 2- (HER2-) negative patients (P=0.00002). As such, patients with a history of previous abortions and who were at stages II, III, and IIII of cancer had higher seropositivity rates than patients without a history of previous abortions or who were at stage I cancer, but the statistical analysis was not significant. We did not find a statistically significant association between T. gondii seropositivity and other risk factors of toxoplasmosis (e.g., education level, type of water source, washing raw fruits and vegetables, consumption of raw or undercooked meat, and contact with soil, cats, and domestic animal). Conclusion. A high seroprevalence rate of latent T. gondii infection was detected among patients with breast cancer; hence, these patients may be at high risk for reactivation of latent infection. Screening of T. gondii infection is recommended to detect active infection among patients with malignancies.http://dx.doi.org/10.1155/2023/4792260 |
| spellingShingle | Marzeieh Haghbin Salar Maani Mohammad Aref Bagherzadeh Ahmadreza Bazmjoo Heshmatollah Shakeri Ali Taghipour Shahab Falahi Azra Kenarkoohi Milad Badri Amir Abdoli Latent Toxoplasmosis among Breast Cancer Patients in Jahrom, South of Iran International Journal of Breast Cancer |
| title | Latent Toxoplasmosis among Breast Cancer Patients in Jahrom, South of Iran |
| title_full | Latent Toxoplasmosis among Breast Cancer Patients in Jahrom, South of Iran |
| title_fullStr | Latent Toxoplasmosis among Breast Cancer Patients in Jahrom, South of Iran |
| title_full_unstemmed | Latent Toxoplasmosis among Breast Cancer Patients in Jahrom, South of Iran |
| title_short | Latent Toxoplasmosis among Breast Cancer Patients in Jahrom, South of Iran |
| title_sort | latent toxoplasmosis among breast cancer patients in jahrom south of iran |
| url | http://dx.doi.org/10.1155/2023/4792260 |
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