The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation
Mitochondrial dysfunction has been established as a common feature of neurodegenerative disorders that contributes to disease pathology by causing impaired cellular energy production. Mitochondrial molecules released into the extracellular space following neuronal damage or death may also play a rol...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/4050796 |
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| _version_ | 1832564349784293376 |
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| author | Ekta Bajwa Caitlin B. Pointer Andis Klegeris |
| author_facet | Ekta Bajwa Caitlin B. Pointer Andis Klegeris |
| author_sort | Ekta Bajwa |
| collection | DOAJ |
| description | Mitochondrial dysfunction has been established as a common feature of neurodegenerative disorders that contributes to disease pathology by causing impaired cellular energy production. Mitochondrial molecules released into the extracellular space following neuronal damage or death may also play a role in these diseases by acting as signaling molecules called damage-associated molecular patterns (DAMPs). Mitochondrial DAMPs have been shown to initiate proinflammatory immune responses from nonneuronal glial cells, including microglia and astrocytes; thereby, they have the potential to contribute to the chronic neuroinflammation present in these disorders accelerating the degeneration of neurons. In this review, we highlight the mitochondrial DAMPs cytochrome c (CytC), mitochondrial transcription factor A (TFAM), and cardiolipin and explore their potential role in the central nervous system disorders including Alzheimer’s disease and Parkinson’s disease, which are characterized by neurodegeneration and chronic neuroinflammation. |
| format | Article |
| id | doaj-art-a8bf905dbb3842b2a5ea61ab7e0f4a4c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a8bf905dbb3842b2a5ea61ab7e0f4a4c2025-02-03T01:11:14ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/40507964050796The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic NeuroinflammationEkta Bajwa0Caitlin B. Pointer1Andis Klegeris2Department of Biology, University of British Columbia Okanagan Campus, Kelowna, BC, CanadaDepartment of Biology, University of British Columbia Okanagan Campus, Kelowna, BC, CanadaDepartment of Biology, University of British Columbia Okanagan Campus, Kelowna, BC, CanadaMitochondrial dysfunction has been established as a common feature of neurodegenerative disorders that contributes to disease pathology by causing impaired cellular energy production. Mitochondrial molecules released into the extracellular space following neuronal damage or death may also play a role in these diseases by acting as signaling molecules called damage-associated molecular patterns (DAMPs). Mitochondrial DAMPs have been shown to initiate proinflammatory immune responses from nonneuronal glial cells, including microglia and astrocytes; thereby, they have the potential to contribute to the chronic neuroinflammation present in these disorders accelerating the degeneration of neurons. In this review, we highlight the mitochondrial DAMPs cytochrome c (CytC), mitochondrial transcription factor A (TFAM), and cardiolipin and explore their potential role in the central nervous system disorders including Alzheimer’s disease and Parkinson’s disease, which are characterized by neurodegeneration and chronic neuroinflammation.http://dx.doi.org/10.1155/2019/4050796 |
| spellingShingle | Ekta Bajwa Caitlin B. Pointer Andis Klegeris The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation Mediators of Inflammation |
| title | The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation |
| title_full | The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation |
| title_fullStr | The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation |
| title_full_unstemmed | The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation |
| title_short | The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation |
| title_sort | role of mitochondrial damage associated molecular patterns in chronic neuroinflammation |
| url | http://dx.doi.org/10.1155/2019/4050796 |
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