A window into the vascular endothelium in COVID-19: Nails
Introduction: Endothelial damage is associated with acute and long-term Coronavirus disease 2019 (COVID-19) complications. Proximal nailfold capillaries are windows for monitoring important microvascular changes associated with endothelial dysfunction. Objective: We aimed to use dermoscopy to exa...
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Mattioli1885
2025-01-01
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| Series: | Dermatology Practical & Conceptual |
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| Online Access: | https://dpcj.org/index.php/dpc/article/view/4927 |
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| author | Ozge Sevil Karstarli Bakay Niyazi Cetin Umut Bakay Gokhan Cinar Sule Goksin |
| author_facet | Ozge Sevil Karstarli Bakay Niyazi Cetin Umut Bakay Gokhan Cinar Sule Goksin |
| author_sort | Ozge Sevil Karstarli Bakay |
| collection | DOAJ |
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Introduction: Endothelial damage is associated with acute and long-term Coronavirus disease 2019 (COVID-19) complications. Proximal nailfold capillaries are windows for monitoring important microvascular changes associated with endothelial dysfunction.
Objective: We aimed to use dermoscopy to examine the proximal nailfold capillaries of COVID-19 patients and identify microvascular changes.
Methods: A prospective study was designed to evaluate the dermoscopic features of proximal nail fold capillaries in mild to moderate COVID-19 patients and healthy controls between June 2022 and December 2023. The patients underwent their initial dermoscopic examination 2 weeks after the onset of symptoms, followed by a follow-up evaluation 10-14 months later.
Results: The study included 46 patients with mild-to-moderate COVID-19 and 62 healthy controls. The presence of avascular areas (P<0.001), meandering capillaries (P=0.016), microhemorrhages (P=0.007), and enlarged capillaries (p=0.009) in the proximal nail fold is significantly higher in COVID-19 patients than in healthy controls The capillary architecture was disorganized (P=0.002) and density reduced (P<0.001) in COVID-19 patients compared to healthy controls. In the follow-up examination, microvascular changes were observed to regress.
Conclusions: Proximal nailfold dermoscopy is an effective, low-cost, and easily accessible method that enables observing microvascular changes in COVID-19 patients.
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| format | Article |
| id | doaj-art-a8b8082dbc054f4ea6dcb0b7a85f731f |
| institution | Kabale University |
| issn | 2160-9381 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Mattioli1885 |
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| series | Dermatology Practical & Conceptual |
| spelling | doaj-art-a8b8082dbc054f4ea6dcb0b7a85f731f2025-02-04T15:41:27ZengMattioli1885Dermatology Practical & Conceptual2160-93812025-01-0115110.5826/dpc.1501a4927A window into the vascular endothelium in COVID-19: NailsOzge Sevil Karstarli Bakay0Niyazi Cetin1Umut Bakay2Gokhan Cinar 3Sule Goksin4Pamukkale University Faculty of Medicine, Department of Dermatology, Denizli, TurkeyPamukkale University Faculty of Medicine, Department of Dermatology, Denizli, TurkeyDenizli State Hospital, Department of Rheumatology, Denizli, TurkeyAgrı Training And Research Hospital, Department of Dermatology, Agrı, TurkeyPamukkale University Faculty of Medicine, Department of Dermatology, Denizli, Turkey Introduction: Endothelial damage is associated with acute and long-term Coronavirus disease 2019 (COVID-19) complications. Proximal nailfold capillaries are windows for monitoring important microvascular changes associated with endothelial dysfunction. Objective: We aimed to use dermoscopy to examine the proximal nailfold capillaries of COVID-19 patients and identify microvascular changes. Methods: A prospective study was designed to evaluate the dermoscopic features of proximal nail fold capillaries in mild to moderate COVID-19 patients and healthy controls between June 2022 and December 2023. The patients underwent their initial dermoscopic examination 2 weeks after the onset of symptoms, followed by a follow-up evaluation 10-14 months later. Results: The study included 46 patients with mild-to-moderate COVID-19 and 62 healthy controls. The presence of avascular areas (P<0.001), meandering capillaries (P=0.016), microhemorrhages (P=0.007), and enlarged capillaries (p=0.009) in the proximal nail fold is significantly higher in COVID-19 patients than in healthy controls The capillary architecture was disorganized (P=0.002) and density reduced (P<0.001) in COVID-19 patients compared to healthy controls. In the follow-up examination, microvascular changes were observed to regress. Conclusions: Proximal nailfold dermoscopy is an effective, low-cost, and easily accessible method that enables observing microvascular changes in COVID-19 patients. https://dpcj.org/index.php/dpc/article/view/4927Proximal nailfold dermoscopyCOVID-19Capillaroscopy |
| spellingShingle | Ozge Sevil Karstarli Bakay Niyazi Cetin Umut Bakay Gokhan Cinar Sule Goksin A window into the vascular endothelium in COVID-19: Nails Dermatology Practical & Conceptual Proximal nailfold dermoscopy COVID-19 Capillaroscopy |
| title | A window into the vascular endothelium in COVID-19: Nails |
| title_full | A window into the vascular endothelium in COVID-19: Nails |
| title_fullStr | A window into the vascular endothelium in COVID-19: Nails |
| title_full_unstemmed | A window into the vascular endothelium in COVID-19: Nails |
| title_short | A window into the vascular endothelium in COVID-19: Nails |
| title_sort | window into the vascular endothelium in covid 19 nails |
| topic | Proximal nailfold dermoscopy COVID-19 Capillaroscopy |
| url | https://dpcj.org/index.php/dpc/article/view/4927 |
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