Multi-omics unveils BCAA metabolism markers L-leucine and HMGCS1 as prognostic marker for immunotherapy efficacy in non-small cell lung cancer

Multi-omics unveils BCAA metabolism markers L-leucine and HMGCS1 as prognostic marker for immunotherapy efficacy in non-small cell lung cancer

Abstract Background This study aims to identify branched-chain amino acid (BCAA) plasma metabolites and gene signatures that enhance prognostic assessments in non-small cell lung cancer (NSCLC) patients receiving immunotherapy. Methods Plasma metabolites were measured using untargeted UPLC-MS/MS (n ...

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Bibliographic Details
Main Authors: Liyuan Dai, Xinzheng Wang, Ning Lou, Lin Li, Liling Huang, Le Tang, Jiarui Yao, Yuankai Shi, Xiaohong Han
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Respiratory Research
Subjects:
Branched chain amino acids
Cholesterol homeostasis
Immunotherapy
Prognostic biomarker
Non-small cell lung cancer
Online Access:https://doi.org/10.1186/s12931-025-03277-8
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