A novel chronic obstructive pulmonary disease mouse model induced by intubation-mediated intratracheal co-administration of porcine pancreatic elastase and lipopolysaccharide

A novel chronic obstructive pulmonary disease mouse model induced by intubation-mediated intratracheal co-administration of porcine pancreatic elastase and lipopolysaccharide

Abstract Background Chronic obstructive pulmonary disease (COPD) is a significant respiratory disorder in humans characterized by persistent airway constriction or obstruction due to chronic bronchitis and pulmonary emphysema. Various methods of inducing COPD in mouse models are frequently used in C...

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Main Authors:	Won-Yong Shim, Sun-Min Seo, Dong-Hyun Kim, Young-Jun Park, Na-Won Kim, Eun-Seon Yoo, Ji-Hun Lee, Han-Bi Jeong, Jin-Hee Seo, Kyoung-Sun Lee, Yang-Kyu Choi
Format:	Article
Language:	English
Published:	BMC 2024-11-01
Series:	BMC Pulmonary Medicine
Subjects:	Chronic obstructive pulmonary disease Porcine pancreatic elastase Lipopolysaccharide Pulmonary emphysema Chronic bronchitis
Online Access:	https://doi.org/10.1186/s12890-024-03365-3
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