Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled Trial
Background. Postpartum preeclampsia is a serious disease related to high blood pressure that occurs commonly within the first six days after delivery. Objective. To evaluate if diltiazem improves blood pressure parameters in early puerperium patients with severe preeclampsia. Methodology. A randomiz...
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| Format: | Article |
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Wiley
2020-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2020/5347918 |
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| author | Gilberto Arias-Hernández Cruz Vargas-De-León Claudia C Calzada-Mendoza María Esther Ocharan-Hernández |
| author_facet | Gilberto Arias-Hernández Cruz Vargas-De-León Claudia C Calzada-Mendoza María Esther Ocharan-Hernández |
| author_sort | Gilberto Arias-Hernández |
| collection | DOAJ |
| description | Background. Postpartum preeclampsia is a serious disease related to high blood pressure that occurs commonly within the first six days after delivery. Objective. To evaluate if diltiazem improves blood pressure parameters in early puerperium patients with severe preeclampsia. Methodology. A randomized, single-blind longitudinal clinical trial of 42 puerperal patients with severe preeclampsia was carried out. Patients were randomized into two groups: the experimental group (n = 21) received diltiazem (60 mg) and the control group (n = 21) received nifedipine (10 mg). Both drugs were orally administered every 8 hours. Systolic, diastolic, and mean blood pressures as well as the heart rate were recorded and analyzed (two-way repeated measures ANOVA) at baseline and after 6, 12, 18, 24, 30, 36, 42, and 48 hours. Primary outcome measures were all the aforementioned blood pressure parameters. Secondary outcome measures included the number of hypertension and hypotension episodes along with the length of stay in the intensive care unit. Results. No statistical differences were found between groups (diltiazem vs. nifedipine) regarding basal blood pressure parameters. Interarm differences in blood pressure (systolic, diastolic, and mean) and heart rate were statistically significant between treatment groups from 6 to 48 hours. Patients in the diltiazem group had lower blood pressure levels than patients in the nifedipine group. Significantly, patients who received diltiazem had fewer hypertension and hypotension episodes and stayed fewer days in the intensive care unit than those treated with nifedipine. Conclusions. Diltiazem controlled arterial hypertension in a more effective and uniform manner in patients under study than nifedipine. Patients treated with diltiazem had fewer collateral effects and spent less time in the hospital. This trial is registered with NCT04222855. |
| format | Article |
| id | doaj-art-a8a687187b644b5b94b2d8bc9b3d238d |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
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| series | International Journal of Hypertension |
| spelling | doaj-art-a8a687187b644b5b94b2d8bc9b3d238d2025-02-03T01:05:18ZengWileyInternational Journal of Hypertension2090-03842090-03922020-01-01202010.1155/2020/53479185347918Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled TrialGilberto Arias-Hernández0Cruz Vargas-De-León1Claudia C Calzada-Mendoza2María Esther Ocharan-Hernández3Hospital De La Mujer, Prolongación Salvador Díaz Mirón 374, Colonia Santo Tomas, Delegación Miguel Hidalgo, C. P. 11340, México D. F., MexicoFacultad De Matemáticas, Universidad Autónoma De Guerrero, Chilpancingo, Av. Lázaro Cárdenas S/N, Cd. Universitaria, 39087 Chilpancingo, Guerrero, MexicoInstituto Politécnico Nacional Escuela Superior De Medicina, Plan De San Luis Y Díaz Mirón SN, Col. Casco De Santo Tomás, Delegación Miguel Hidalgo, C. P. 11340, México D. F, MexicoInstituto Politécnico Nacional Escuela Superior De Medicina, Plan De San Luis Y Díaz Mirón SN, Col. Casco De Santo Tomás, Delegación Miguel Hidalgo, C. P. 11340, México D. F, MexicoBackground. Postpartum preeclampsia is a serious disease related to high blood pressure that occurs commonly within the first six days after delivery. Objective. To evaluate if diltiazem improves blood pressure parameters in early puerperium patients with severe preeclampsia. Methodology. A randomized, single-blind longitudinal clinical trial of 42 puerperal patients with severe preeclampsia was carried out. Patients were randomized into two groups: the experimental group (n = 21) received diltiazem (60 mg) and the control group (n = 21) received nifedipine (10 mg). Both drugs were orally administered every 8 hours. Systolic, diastolic, and mean blood pressures as well as the heart rate were recorded and analyzed (two-way repeated measures ANOVA) at baseline and after 6, 12, 18, 24, 30, 36, 42, and 48 hours. Primary outcome measures were all the aforementioned blood pressure parameters. Secondary outcome measures included the number of hypertension and hypotension episodes along with the length of stay in the intensive care unit. Results. No statistical differences were found between groups (diltiazem vs. nifedipine) regarding basal blood pressure parameters. Interarm differences in blood pressure (systolic, diastolic, and mean) and heart rate were statistically significant between treatment groups from 6 to 48 hours. Patients in the diltiazem group had lower blood pressure levels than patients in the nifedipine group. Significantly, patients who received diltiazem had fewer hypertension and hypotension episodes and stayed fewer days in the intensive care unit than those treated with nifedipine. Conclusions. Diltiazem controlled arterial hypertension in a more effective and uniform manner in patients under study than nifedipine. Patients treated with diltiazem had fewer collateral effects and spent less time in the hospital. This trial is registered with NCT04222855.http://dx.doi.org/10.1155/2020/5347918 |
| spellingShingle | Gilberto Arias-Hernández Cruz Vargas-De-León Claudia C Calzada-Mendoza María Esther Ocharan-Hernández Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled Trial International Journal of Hypertension |
| title | Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled Trial |
| title_full | Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled Trial |
| title_fullStr | Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled Trial |
| title_full_unstemmed | Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled Trial |
| title_short | Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled Trial |
| title_sort | efficacy of diltiazem for the control of blood pressure in puerperal patients with severe preeclampsia a randomized single blind controlled trial |
| url | http://dx.doi.org/10.1155/2020/5347918 |
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