The Evolving Epidemiology of Helicobacter pylori Infection and Gastric Cancer
The relationship between Helicobacter pylori infection and the risk of gastric cancer has been well established in the last decade. Four metaanalyses have found that the infection increases the risk of noncardia gastric cancer by 2- to 6-fold compared with noninfected control populations. However, t...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2003/692808 |
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| _version_ | 1832567251075596288 |
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| author | Jia-Qing Huang Richard H Hunt |
| author_facet | Jia-Qing Huang Richard H Hunt |
| author_sort | Jia-Qing Huang |
| collection | DOAJ |
| description | The relationship between Helicobacter pylori infection and the risk of
gastric cancer has been well established in the last decade. Four metaanalyses
have found that the infection increases the risk of noncardia
gastric cancer by 2- to 6-fold compared with noninfected control populations.
However, the role of cagA strains of H pylori in relation to
gastric cancer has not been evaluated systematically. We undertook a
meta-analysis of epidemiological studies examining the relationship
between infection with cagA-positive strains of H pylori and the risk of
gastric cancer, and found that patients who are seropositive for cagA
strains of H pylori are at an increased risk for developing noncardia
gastric cancer compared with those with H pylori infection alone.
Therefore, searching for cagA-positive strains of H pylori may help
identify populations at a greater risk for developing gastric cancer. |
| format | Article |
| id | doaj-art-a89d782e98844b0eb2546f2abc923a21 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-a89d782e98844b0eb2546f2abc923a212025-02-03T01:01:58ZengWileyCanadian Journal of Gastroenterology0835-79002003-01-0117Suppl B18B20B10.1155/2003/692808The Evolving Epidemiology of Helicobacter pylori Infection and Gastric CancerJia-Qing Huang0Richard H Hunt1Division of Gastroenterology, Department of Medicine, McMaster University Medical Center, Hamilton, Ontario, CanadaDivision of Gastroenterology, Department of Medicine, McMaster University Medical Center, Hamilton, Ontario, CanadaThe relationship between Helicobacter pylori infection and the risk of gastric cancer has been well established in the last decade. Four metaanalyses have found that the infection increases the risk of noncardia gastric cancer by 2- to 6-fold compared with noninfected control populations. However, the role of cagA strains of H pylori in relation to gastric cancer has not been evaluated systematically. We undertook a meta-analysis of epidemiological studies examining the relationship between infection with cagA-positive strains of H pylori and the risk of gastric cancer, and found that patients who are seropositive for cagA strains of H pylori are at an increased risk for developing noncardia gastric cancer compared with those with H pylori infection alone. Therefore, searching for cagA-positive strains of H pylori may help identify populations at a greater risk for developing gastric cancer.http://dx.doi.org/10.1155/2003/692808 |
| spellingShingle | Jia-Qing Huang Richard H Hunt The Evolving Epidemiology of Helicobacter pylori Infection and Gastric Cancer Canadian Journal of Gastroenterology |
| title | The Evolving Epidemiology of Helicobacter pylori Infection and Gastric Cancer |
| title_full | The Evolving Epidemiology of Helicobacter pylori Infection and Gastric Cancer |
| title_fullStr | The Evolving Epidemiology of Helicobacter pylori Infection and Gastric Cancer |
| title_full_unstemmed | The Evolving Epidemiology of Helicobacter pylori Infection and Gastric Cancer |
| title_short | The Evolving Epidemiology of Helicobacter pylori Infection and Gastric Cancer |
| title_sort | evolving epidemiology of helicobacter pylori infection and gastric cancer |
| url | http://dx.doi.org/10.1155/2003/692808 |
| work_keys_str_mv | AT jiaqinghuang theevolvingepidemiologyofhelicobacterpyloriinfectionandgastriccancer AT richardhhunt theevolvingepidemiologyofhelicobacterpyloriinfectionandgastriccancer AT jiaqinghuang evolvingepidemiologyofhelicobacterpyloriinfectionandgastriccancer AT richardhhunt evolvingepidemiologyofhelicobacterpyloriinfectionandgastriccancer |