The Evolving Epidemiology of Helicobacter pylori Infection and Gastric Cancer
The relationship between Helicobacter pylori infection and the risk of gastric cancer has been well established in the last decade. Four metaanalyses have found that the infection increases the risk of noncardia gastric cancer by 2- to 6-fold compared with noninfected control populations. However, t...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2003-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2003/692808 |
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| Summary: | The relationship between Helicobacter pylori infection and the risk of
gastric cancer has been well established in the last decade. Four metaanalyses
have found that the infection increases the risk of noncardia
gastric cancer by 2- to 6-fold compared with noninfected control populations.
However, the role of cagA strains of H pylori in relation to
gastric cancer has not been evaluated systematically. We undertook a
meta-analysis of epidemiological studies examining the relationship
between infection with cagA-positive strains of H pylori and the risk of
gastric cancer, and found that patients who are seropositive for cagA
strains of H pylori are at an increased risk for developing noncardia
gastric cancer compared with those with H pylori infection alone.
Therefore, searching for cagA-positive strains of H pylori may help
identify populations at a greater risk for developing gastric cancer. |
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| ISSN: | 0835-7900 |