Does Preoperative Radio(chemo)therapy Increase Anastomotic Leakage in Rectal Cancer Surgery? A Meta-Analysis of Randomized Controlled Trials
Objective. Preoperative radio(chemo)therapy (pR(C)T) appears to increase postoperative complications of rectal cancer resection, but clinical trials have reported conflicting results. The objective of this meta-analysis was performed to assess the effects of pR(C)T on anastomotic leak after rectal c...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/910956 |
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| _version_ | 1832559301417238528 |
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| author | Changjiang Qin Xuequn Ren Kaiwu Xu Zhihui Chen Yulong He Xinming Song |
| author_facet | Changjiang Qin Xuequn Ren Kaiwu Xu Zhihui Chen Yulong He Xinming Song |
| author_sort | Changjiang Qin |
| collection | DOAJ |
| description | Objective. Preoperative radio(chemo)therapy (pR(C)T) appears to increase postoperative complications of rectal cancer resection, but clinical trials have reported conflicting results. The objective of this meta-analysis was performed to assess the effects of pR(C)T on anastomotic leak after rectal cancer resection. Methods. PubMed, Embase, and the Cochrane Library were searched from January 1980 to January 2014. Randomized controlled trials included all original articles reporting anastomotic leak in patients with rectal cancer, among whom some received preoperative radiotherapy or chemoradiotherapy while others did not. The analysed end-points were the anastomotic leak. Result. Seven randomized controlled trials with 3375 patients were included in the meta-analysis. 1660 forming the group undergoing preoperative radiotherapy or chemoradiotherapy versus 1715 patients undergoing without preoperative radiotherapy or chemoradiotherapy. The meta-analyses found that pR(C)T was not an independent risk factor for anastomotic leakage (OR 1.02, 95% CI 0.80–1.30; P=0.88). Subgroups analysis was performed and the result was not altered. Conclusions. Current evidence demonstrates that pR(C)T did not increase the risk of postoperative anastomotic leak after rectal cancer resection in patients. |
| format | Article |
| id | doaj-art-a8810e3ca9f2497f8a9421e454014983 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-a8810e3ca9f2497f8a9421e4540149832025-02-03T01:30:28ZengWileyGastroenterology Research and Practice1687-61211687-630X2014-01-01201410.1155/2014/910956910956Does Preoperative Radio(chemo)therapy Increase Anastomotic Leakage in Rectal Cancer Surgery? A Meta-Analysis of Randomized Controlled TrialsChangjiang Qin0Xuequn Ren1Kaiwu Xu2Zhihui Chen3Yulong He4Xinming Song5Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Zhongshan Second Road, Guangzhou, Guangdong 510080, ChinaDepartment of Gastrointestinal Surgery, Huai He Hospital of Henan University, Kaifeng, ChinaDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Zhongshan Second Road, Guangzhou, Guangdong 510080, ChinaDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Zhongshan Second Road, Guangzhou, Guangdong 510080, ChinaDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Zhongshan Second Road, Guangzhou, Guangdong 510080, ChinaDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Zhongshan Second Road, Guangzhou, Guangdong 510080, ChinaObjective. Preoperative radio(chemo)therapy (pR(C)T) appears to increase postoperative complications of rectal cancer resection, but clinical trials have reported conflicting results. The objective of this meta-analysis was performed to assess the effects of pR(C)T on anastomotic leak after rectal cancer resection. Methods. PubMed, Embase, and the Cochrane Library were searched from January 1980 to January 2014. Randomized controlled trials included all original articles reporting anastomotic leak in patients with rectal cancer, among whom some received preoperative radiotherapy or chemoradiotherapy while others did not. The analysed end-points were the anastomotic leak. Result. Seven randomized controlled trials with 3375 patients were included in the meta-analysis. 1660 forming the group undergoing preoperative radiotherapy or chemoradiotherapy versus 1715 patients undergoing without preoperative radiotherapy or chemoradiotherapy. The meta-analyses found that pR(C)T was not an independent risk factor for anastomotic leakage (OR 1.02, 95% CI 0.80–1.30; P=0.88). Subgroups analysis was performed and the result was not altered. Conclusions. Current evidence demonstrates that pR(C)T did not increase the risk of postoperative anastomotic leak after rectal cancer resection in patients.http://dx.doi.org/10.1155/2014/910956 |
| spellingShingle | Changjiang Qin Xuequn Ren Kaiwu Xu Zhihui Chen Yulong He Xinming Song Does Preoperative Radio(chemo)therapy Increase Anastomotic Leakage in Rectal Cancer Surgery? A Meta-Analysis of Randomized Controlled Trials Gastroenterology Research and Practice |
| title | Does Preoperative Radio(chemo)therapy Increase Anastomotic Leakage in Rectal Cancer Surgery? A Meta-Analysis of Randomized Controlled Trials |
| title_full | Does Preoperative Radio(chemo)therapy Increase Anastomotic Leakage in Rectal Cancer Surgery? A Meta-Analysis of Randomized Controlled Trials |
| title_fullStr | Does Preoperative Radio(chemo)therapy Increase Anastomotic Leakage in Rectal Cancer Surgery? A Meta-Analysis of Randomized Controlled Trials |
| title_full_unstemmed | Does Preoperative Radio(chemo)therapy Increase Anastomotic Leakage in Rectal Cancer Surgery? A Meta-Analysis of Randomized Controlled Trials |
| title_short | Does Preoperative Radio(chemo)therapy Increase Anastomotic Leakage in Rectal Cancer Surgery? A Meta-Analysis of Randomized Controlled Trials |
| title_sort | does preoperative radio chemo therapy increase anastomotic leakage in rectal cancer surgery a meta analysis of randomized controlled trials |
| url | http://dx.doi.org/10.1155/2014/910956 |
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