Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway

Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway

ABSTRACT Objective: Diabetic neuropathy (DN) is an important complication of diabetes mellitus. Autophagy is considered to be potentially involved in the regulation of DN. Metformin is broadly utilized in the first-line treatment of diabetes. The present work aimed to assess whether and how metform...

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Bibliographic Details
Main Authors: Fangqin You, Diya Xie, Cheng Li, Lihang Yang, Fengmin Liu
Format: Article
Language:English
Published: Brazilian Society of Endocrinology and Metabolism 2025-01-01
Series:Archives of Endocrinology and Metabolism
Subjects:
Diabetes
diabetic neuropathy
metformin
autophagy
AMPK
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000307&lng=en&tlng=en
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