Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway
ABSTRACT Objective: Diabetic neuropathy (DN) is an important complication of diabetes mellitus. Autophagy is considered to be potentially involved in the regulation of DN. Metformin is broadly utilized in the first-line treatment of diabetes. The present work aimed to assess whether and how metform...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2025-01-01
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| Series: | Archives of Endocrinology and Metabolism |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000307&lng=en&tlng=en |
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| author | Fangqin You Diya Xie Cheng Li Lihang Yang Fengmin Liu |
| author_facet | Fangqin You Diya Xie Cheng Li Lihang Yang Fengmin Liu |
| author_sort | Fangqin You |
| collection | DOAJ |
| description | ABSTRACT Objective: Diabetic neuropathy (DN) is an important complication of diabetes mellitus. Autophagy is considered to be potentially involved in the regulation of DN. Metformin is broadly utilized in the first-line treatment of diabetes. The present work aimed to assess whether and how metformin exerts protective effects in DN. Materials and methods: A DN rat model induced by streptozotocin (STZ) was established. Metformin was administered to examine its effect on sciatic nerve pathology, and the possible mechanisms involved in this process were explored. Results: Morphological damage was observed in sciatic nerve samples from diabetic animals, accompanied by decreased p-AMPK expression and increased LC-3 levels. Notably, metformin ameliorated the morphological changes in the sciatic nerve by downregulating autophagy via p-AMPK upregulation. Conclusions: These results indicate that metformin attenuates peripheral neuropathy in diabetic rats by regulating autophagy. |
| format | Article |
| id | doaj-art-a87c3914a93e4c1dbf5774621539ce49 |
| institution | Kabale University |
| issn | 2359-4292 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj-art-a87c3914a93e4c1dbf5774621539ce492025-01-21T07:45:00ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922025-01-0168spe110.20945/2359-4292-2024-0137Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathwayFangqin Youhttps://orcid.org/0009-0002-3561-5446Diya Xiehttps://orcid.org/0000-0001-9062-624XCheng Lihttps://orcid.org/0009-0001-4761-1752Lihang Yanghttps://orcid.org/0000-0002-8219-9089Fengmin Liuhttps://orcid.org/0000-0002-0315-2750ABSTRACT Objective: Diabetic neuropathy (DN) is an important complication of diabetes mellitus. Autophagy is considered to be potentially involved in the regulation of DN. Metformin is broadly utilized in the first-line treatment of diabetes. The present work aimed to assess whether and how metformin exerts protective effects in DN. Materials and methods: A DN rat model induced by streptozotocin (STZ) was established. Metformin was administered to examine its effect on sciatic nerve pathology, and the possible mechanisms involved in this process were explored. Results: Morphological damage was observed in sciatic nerve samples from diabetic animals, accompanied by decreased p-AMPK expression and increased LC-3 levels. Notably, metformin ameliorated the morphological changes in the sciatic nerve by downregulating autophagy via p-AMPK upregulation. Conclusions: These results indicate that metformin attenuates peripheral neuropathy in diabetic rats by regulating autophagy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000307&lng=en&tlng=enDiabetesdiabetic neuropathymetforminautophagyAMPK |
| spellingShingle | Fangqin You Diya Xie Cheng Li Lihang Yang Fengmin Liu Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway Archives of Endocrinology and Metabolism Diabetes diabetic neuropathy metformin autophagy AMPK |
| title | Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway |
| title_full | Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway |
| title_fullStr | Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway |
| title_full_unstemmed | Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway |
| title_short | Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway |
| title_sort | metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the ampk pathway |
| topic | Diabetes diabetic neuropathy metformin autophagy AMPK |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000307&lng=en&tlng=en |
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