Pouchitis unveiled: exploring clinical features, diagnosis, and cutting-edge treatments
Last decades led to a revolution in the management of ulcerative colitis (UC), due to the development of novel advanced therapies and the identification of increasingly ambitious therapeutic goals. Nevertheless, a subset of patients, refractory to available therapies, still requires proctocolectomy...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Therapeutic Advances in Gastroenterology |
| Online Access: | https://doi.org/10.1177/17562848251316412 |
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| author | Francesca Lusetti Camilla Almeida Martins Helfenberger Munique Kurtz de Mello Natália Sousa Freitas Queiroz |
| author_facet | Francesca Lusetti Camilla Almeida Martins Helfenberger Munique Kurtz de Mello Natália Sousa Freitas Queiroz |
| author_sort | Francesca Lusetti |
| collection | DOAJ |
| description | Last decades led to a revolution in the management of ulcerative colitis (UC), due to the development of novel advanced therapies and the identification of increasingly ambitious therapeutic goals. Nevertheless, a subset of patients, refractory to available therapies, still requires proctocolectomy with ileal pouch-anal anastomosis (IPAA). Pouchitis, an inflammatory condition of the ileal pouch, is the most common long-term complication of IPAA, affecting almost one-half of patients in the first 10 years after surgery. Symptoms of pouchitis include increased stool frequency, urgency, and abdominal discomfort, significantly affecting patients’ quality of life. Traditionally the mainstay treatment of acute pouchitis involves the use of antibiotics, but one-fifth of patients develop chronic pouchitis (CP), which may be dependent or resistant to antibiotics, posing significant challenges in the management of this condition. Currently, there is still no consensus on the optimal management for CP, though recent progress in understanding the pathophysiology of pouchitis has paved the way for innovative therapeutic approaches, based on biological therapies and small molecules. This review aims to discuss the recent advanced therapies available for pouchitis and provide a comprehensive review on the topic to guide physicians in their clinical practice. |
| format | Article |
| id | doaj-art-a86f70c47c58414bbb9f6f16d0c0a780 |
| institution | Kabale University |
| issn | 1756-2848 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Gastroenterology |
| spelling | doaj-art-a86f70c47c58414bbb9f6f16d0c0a7802025-01-27T17:03:20ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-28482025-01-011810.1177/17562848251316412Pouchitis unveiled: exploring clinical features, diagnosis, and cutting-edge treatmentsFrancesca LusettiCamilla Almeida Martins HelfenbergerMunique Kurtz de MelloNatália Sousa Freitas QueirozLast decades led to a revolution in the management of ulcerative colitis (UC), due to the development of novel advanced therapies and the identification of increasingly ambitious therapeutic goals. Nevertheless, a subset of patients, refractory to available therapies, still requires proctocolectomy with ileal pouch-anal anastomosis (IPAA). Pouchitis, an inflammatory condition of the ileal pouch, is the most common long-term complication of IPAA, affecting almost one-half of patients in the first 10 years after surgery. Symptoms of pouchitis include increased stool frequency, urgency, and abdominal discomfort, significantly affecting patients’ quality of life. Traditionally the mainstay treatment of acute pouchitis involves the use of antibiotics, but one-fifth of patients develop chronic pouchitis (CP), which may be dependent or resistant to antibiotics, posing significant challenges in the management of this condition. Currently, there is still no consensus on the optimal management for CP, though recent progress in understanding the pathophysiology of pouchitis has paved the way for innovative therapeutic approaches, based on biological therapies and small molecules. This review aims to discuss the recent advanced therapies available for pouchitis and provide a comprehensive review on the topic to guide physicians in their clinical practice.https://doi.org/10.1177/17562848251316412 |
| spellingShingle | Francesca Lusetti Camilla Almeida Martins Helfenberger Munique Kurtz de Mello Natália Sousa Freitas Queiroz Pouchitis unveiled: exploring clinical features, diagnosis, and cutting-edge treatments Therapeutic Advances in Gastroenterology |
| title | Pouchitis unveiled: exploring clinical features, diagnosis, and cutting-edge treatments |
| title_full | Pouchitis unveiled: exploring clinical features, diagnosis, and cutting-edge treatments |
| title_fullStr | Pouchitis unveiled: exploring clinical features, diagnosis, and cutting-edge treatments |
| title_full_unstemmed | Pouchitis unveiled: exploring clinical features, diagnosis, and cutting-edge treatments |
| title_short | Pouchitis unveiled: exploring clinical features, diagnosis, and cutting-edge treatments |
| title_sort | pouchitis unveiled exploring clinical features diagnosis and cutting edge treatments |
| url | https://doi.org/10.1177/17562848251316412 |
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