Investigating the Effect of Testosterone Supplement on Heart and Muscle Damage in Rats Applied with Swimming Exercise
Anabolic Androgenic Steroids which are a synthetic derivative of testosterone are known to be used by some sportsmen in order to improve performance. The present study was conducted to investigate the effect of testosterone supplement on heart and muscle damage in rats applied with swimming exercise...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
2019-04-01
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| Series: | Türk Spor ve Egzersiz Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/713244 |
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| author | Ömer Kulaksız Sefa Lök |
| author_facet | Ömer Kulaksız Sefa Lök |
| author_sort | Ömer Kulaksız |
| collection | DOAJ |
| description | Anabolic
Androgenic Steroids which are a synthetic derivative of testosterone are known
to be used by some sportsmen in order to improve performance. The present study
was conducted to investigate the effect of testosterone supplement on heart and
muscle damage in rats applied with swimming exercise. The study was conducted
on 30 day-old 27 (Wistar, male) rats that were supplied from “Selçuk University
Experimental Medicine Research and Application Center”. The rats were divided
into 4 groups. The rats in control groups (n:6) were fed during the study
without doing any application. The rats in testosteronegroup (n:7) were
supplied with a 10 mg/kg dose of testosterone 5 days a week for 3 weeks. The
rats in exercise group (n:7) did freestyle swimming exercise for 30 minutes a
day for 5 days a weekfor 3 weeks. The rats in testosterone + exercise group
(n:7) did freestyle swimming exercise for 30 minutes and were administered with
10 mg/kg dose of testosterone supplement for 5 days a week for 3 weeks. At the
end of the trial, necessary biochemical parameters were measured in serums
obtained by drawing blood from tails of the rats. While levels of Serum, LDH,
CK-MB, and CKwere studied by using an autoanalyzer, Troponin I level was
analyzed by using ELISA kit. SPSS 15.0 packaged software was usedin statistical
evaluation of the data and the results were given as mean±SE. Since the data
were convenient with the normal distribution, ANOVA test was applied for
betweengroups comparison and Duncan test was used to identify from which group
the difference was resulted. When between-groups values of troponin I, ck-MB,
and LDH, which are indicators of heart damage, and enzyme CK, which is an
indicator of muscle damage,for control, exercise, testosterone, and
testosterone+exercise groups were compared, a statistically significant
difference was determined between control, exercise, testosterone, and
testosterone+exercise groups (p lt;0.05). As a result of statistically analysis
performed on all groups, the difference was found to be caused by testosterone
and testosterone+exercise groups. Because testosterone production is naturally
increased in the body during the exercise, swimming exercise and testosterone
administration led to significant occurrence of troponin I, ck-MB, LDH, which
are heart damage indicators in rats, and CK value, which is an indicator of
muscle damage, in the blood.
Keywords: Testosterone,
Heart, Muscle Damage, Swimming Exercise |
| format | Article |
| id | doaj-art-a86f06c0a11243be96e2994046ed905f |
| institution | Kabale University |
| issn | 2147-5652 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Türk Spor ve Egzersiz Dergisi |
| spelling | doaj-art-a86f06c0a11243be96e2994046ed905f2025-02-03T03:38:46ZengSelcuk University PressTürk Spor ve Egzersiz Dergisi2147-56522019-04-0121117017410.15314/tsed.552893154Investigating the Effect of Testosterone Supplement on Heart and Muscle Damage in Rats Applied with Swimming ExerciseÖmer Kulaksız0Sefa Lök1SELCUK UNIVERSITY, INSTITUTE OF HEALTH SCIENCESFACULTY OF SPORTS SCIENCESAnabolic Androgenic Steroids which are a synthetic derivative of testosterone are known to be used by some sportsmen in order to improve performance. The present study was conducted to investigate the effect of testosterone supplement on heart and muscle damage in rats applied with swimming exercise. The study was conducted on 30 day-old 27 (Wistar, male) rats that were supplied from “Selçuk University Experimental Medicine Research and Application Center”. The rats were divided into 4 groups. The rats in control groups (n:6) were fed during the study without doing any application. The rats in testosteronegroup (n:7) were supplied with a 10 mg/kg dose of testosterone 5 days a week for 3 weeks. The rats in exercise group (n:7) did freestyle swimming exercise for 30 minutes a day for 5 days a weekfor 3 weeks. The rats in testosterone + exercise group (n:7) did freestyle swimming exercise for 30 minutes and were administered with 10 mg/kg dose of testosterone supplement for 5 days a week for 3 weeks. At the end of the trial, necessary biochemical parameters were measured in serums obtained by drawing blood from tails of the rats. While levels of Serum, LDH, CK-MB, and CKwere studied by using an autoanalyzer, Troponin I level was analyzed by using ELISA kit. SPSS 15.0 packaged software was usedin statistical evaluation of the data and the results were given as mean±SE. Since the data were convenient with the normal distribution, ANOVA test was applied for betweengroups comparison and Duncan test was used to identify from which group the difference was resulted. When between-groups values of troponin I, ck-MB, and LDH, which are indicators of heart damage, and enzyme CK, which is an indicator of muscle damage,for control, exercise, testosterone, and testosterone+exercise groups were compared, a statistically significant difference was determined between control, exercise, testosterone, and testosterone+exercise groups (p lt;0.05). As a result of statistically analysis performed on all groups, the difference was found to be caused by testosterone and testosterone+exercise groups. Because testosterone production is naturally increased in the body during the exercise, swimming exercise and testosterone administration led to significant occurrence of troponin I, ck-MB, LDH, which are heart damage indicators in rats, and CK value, which is an indicator of muscle damage, in the blood. Keywords: Testosterone, Heart, Muscle Damage, Swimming Exercisehttps://dergipark.org.tr/tr/download/article-file/713244testosteroneheartmuscle damage |
| spellingShingle | Ömer Kulaksız Sefa Lök Investigating the Effect of Testosterone Supplement on Heart and Muscle Damage in Rats Applied with Swimming Exercise Türk Spor ve Egzersiz Dergisi testosterone heart muscle damage |
| title | Investigating the Effect of Testosterone Supplement on Heart and Muscle Damage in Rats Applied with Swimming Exercise |
| title_full | Investigating the Effect of Testosterone Supplement on Heart and Muscle Damage in Rats Applied with Swimming Exercise |
| title_fullStr | Investigating the Effect of Testosterone Supplement on Heart and Muscle Damage in Rats Applied with Swimming Exercise |
| title_full_unstemmed | Investigating the Effect of Testosterone Supplement on Heart and Muscle Damage in Rats Applied with Swimming Exercise |
| title_short | Investigating the Effect of Testosterone Supplement on Heart and Muscle Damage in Rats Applied with Swimming Exercise |
| title_sort | investigating the effect of testosterone supplement on heart and muscle damage in rats applied with swimming exercise |
| topic | testosterone heart muscle damage |
| url | https://dergipark.org.tr/tr/download/article-file/713244 |
| work_keys_str_mv | AT omerkulaksız investigatingtheeffectoftestosteronesupplementonheartandmuscledamageinratsappliedwithswimmingexercise AT sefalok investigatingtheeffectoftestosteronesupplementonheartandmuscledamageinratsappliedwithswimmingexercise |