Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
<h4>Background</h4>Prior work suggested that patients with inflammatory bowel diseases (IBD) have lower body mass index (BMI) than controls and patients with lower BMI have more serious complications.<h4>Goal</h4>The study was aimed to find relationship between BMI in patient...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0144872 |
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| author | Jie Dong Yi Chen Yuchen Tang Fei Xu Chaohui Yu Youming Li Prasoon Pankaj Ning Dai |
| author_facet | Jie Dong Yi Chen Yuchen Tang Fei Xu Chaohui Yu Youming Li Prasoon Pankaj Ning Dai |
| author_sort | Jie Dong |
| collection | DOAJ |
| description | <h4>Background</h4>Prior work suggested that patients with inflammatory bowel diseases (IBD) have lower body mass index (BMI) than controls and patients with lower BMI have more serious complications.<h4>Goal</h4>The study was aimed to find relationship between BMI in patients with and without IBD, investigate effects of medicine therapy and disease stages on patients' BMI.<h4>Methods</h4>Potentially eligible studies were identified through searching PubMed, Cochrane and Embase databases. Outcome measurements of mean BMI and the number of patients from each study were pooled by a random-effect model. Publication bias test, sensitivity analysis and subgroup analysis were conducted.<h4>Results</h4>A total of 24 studies containing 1442 patients and 2059 controls were included. Main results were as follows: (1) BMI in Crohn's disease (CD) patients was lower than that in health controls (-1.88, 95% CI -2.77 to -1.00, P< 0.001); (2) Medical therapy significantly improved BMI of CD patients (with therapy: -1.58, -3.33 to 0.16; without: -2.09, 95% CI -3.21 to -0.98) while on the contrary not significantly improving BMI of UC patients (with therapy: -0.24, 95% CI -3.68 to 3.20; without: -1.34, 95% CI -2.87 to 0.20, P = 0.57); (3) Both CD and UC patients in active phase showed significantly greater BMI difference compared with controls than those in remission (CD patients: remission: -2.25, 95% CI -3.38 to -1.11; active phase: -4.25, 95% CI -5.58 to -2.92, P = 0.03; UC patients: remission: 0.4, 95% CI -2.05 to 2.84; active phase: -5.38, -6.78 to -3.97, P = 0.001).<h4>Conclusions</h4>BMI is lower in CD patients; medical therapy couldn't improve BMI of IBD patients; the state of disease affects BMI of CD patients and UC patients. |
| format | Article |
| id | doaj-art-a86c41c822bf45b0843e7d9f78ff13b7 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-a86c41c822bf45b0843e7d9f78ff13b72025-08-20T03:27:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011012e014487210.1371/journal.pone.0144872Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.Jie DongYi ChenYuchen TangFei XuChaohui YuYouming LiPrasoon PankajNing Dai<h4>Background</h4>Prior work suggested that patients with inflammatory bowel diseases (IBD) have lower body mass index (BMI) than controls and patients with lower BMI have more serious complications.<h4>Goal</h4>The study was aimed to find relationship between BMI in patients with and without IBD, investigate effects of medicine therapy and disease stages on patients' BMI.<h4>Methods</h4>Potentially eligible studies were identified through searching PubMed, Cochrane and Embase databases. Outcome measurements of mean BMI and the number of patients from each study were pooled by a random-effect model. Publication bias test, sensitivity analysis and subgroup analysis were conducted.<h4>Results</h4>A total of 24 studies containing 1442 patients and 2059 controls were included. Main results were as follows: (1) BMI in Crohn's disease (CD) patients was lower than that in health controls (-1.88, 95% CI -2.77 to -1.00, P< 0.001); (2) Medical therapy significantly improved BMI of CD patients (with therapy: -1.58, -3.33 to 0.16; without: -2.09, 95% CI -3.21 to -0.98) while on the contrary not significantly improving BMI of UC patients (with therapy: -0.24, 95% CI -3.68 to 3.20; without: -1.34, 95% CI -2.87 to 0.20, P = 0.57); (3) Both CD and UC patients in active phase showed significantly greater BMI difference compared with controls than those in remission (CD patients: remission: -2.25, 95% CI -3.38 to -1.11; active phase: -4.25, 95% CI -5.58 to -2.92, P = 0.03; UC patients: remission: 0.4, 95% CI -2.05 to 2.84; active phase: -5.38, -6.78 to -3.97, P = 0.001).<h4>Conclusions</h4>BMI is lower in CD patients; medical therapy couldn't improve BMI of IBD patients; the state of disease affects BMI of CD patients and UC patients.https://doi.org/10.1371/journal.pone.0144872 |
| spellingShingle | Jie Dong Yi Chen Yuchen Tang Fei Xu Chaohui Yu Youming Li Prasoon Pankaj Ning Dai Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. PLoS ONE |
| title | Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. |
| title_full | Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. |
| title_fullStr | Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. |
| title_full_unstemmed | Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. |
| title_short | Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. |
| title_sort | body mass index is associated with inflammatory bowel disease a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0144872 |
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