Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage
Background. Currently there is no indicator that can evaluate actual liver lesion for early stages of viral hepatitis, nonalcoholic fatty liver disease (NAFLD), and cirrhosis. Aim of this study was to investigate if albumin binding function could better reflect liver function in these liver diseases...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/5120760 |
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| author | Penglei Ge Huayu Yang Jingfen Lu Wenjun Liao Shunda Du Yingli Xu Haifeng Xu Haitao Zhao Xin Lu Xinting Sang Shouxian Zhong Jiefu Huang Yilei Mao |
| author_facet | Penglei Ge Huayu Yang Jingfen Lu Wenjun Liao Shunda Du Yingli Xu Haifeng Xu Haitao Zhao Xin Lu Xinting Sang Shouxian Zhong Jiefu Huang Yilei Mao |
| author_sort | Penglei Ge |
| collection | DOAJ |
| description | Background. Currently there is no indicator that can evaluate actual liver lesion for early stages of viral hepatitis, nonalcoholic fatty liver disease (NAFLD), and cirrhosis. Aim of this study was to investigate if albumin binding function could better reflect liver function in these liver diseases. Methods. An observational study was performed on 193 patients with early NAFLD, viral hepatitis, and cirrhosis. Cirrhosis patients were separated according to Child-Pugh score into A, B, and C subgroup. Albumin metal ion binding capacity (Ischemia-modified albumin transformed, IMAT) and fatty acid binding capacity (total binding sites, TBS) were detected. Results. Both IMAT and TBS were significantly decreased in patients with NAFLD and early hepatitis. In hepatitis group, they declined prior to changes of liver enzymes. IMAT was significantly higher in cirrhosis Child-Pugh class A group than hepatitis patients and decreased in Child-Pugh class B and class C patients. Both IMAT/albumin and TBS/albumin decreased significantly in hepatitis and NAFLD group patients. Conclusions. This is the first study to discover changes of albumin metal ion and fatty acid binding capacities prior to conventional biomarkers for liver damage in early stage of liver diseases. They may become potential earliest sensitive indicators for liver function evaluation. |
| format | Article |
| id | doaj-art-a867cf4bae1a4a339ae37e77878f3fab |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-a867cf4bae1a4a339ae37e77878f3fab2025-02-03T05:58:50ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/51207605120760Albumin Binding Function: The Potential Earliest Indicator for Liver Function DamagePenglei Ge0Huayu Yang1Jingfen Lu2Wenjun Liao3Shunda Du4Yingli Xu5Haifeng Xu6Haitao Zhao7Xin Lu8Xinting Sang9Shouxian Zhong10Jiefu Huang11Yilei Mao12Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences and PUMC, Beijing, ChinaDepartment of Liver Surgery, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences and PUMC, Beijing, ChinaState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, ChinaDepartment of Liver Surgery, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences and PUMC, Beijing, ChinaDepartment of Liver Surgery, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences and PUMC, Beijing, ChinaState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, ChinaDepartment of Liver Surgery, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences and PUMC, Beijing, ChinaDepartment of Liver Surgery, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences and PUMC, Beijing, ChinaDepartment of Liver Surgery, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences and PUMC, Beijing, ChinaDepartment of Liver Surgery, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences and PUMC, Beijing, ChinaDepartment of Liver Surgery, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences and PUMC, Beijing, ChinaDepartment of Liver Surgery, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences and PUMC, Beijing, ChinaDepartment of Liver Surgery, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences and PUMC, Beijing, ChinaBackground. Currently there is no indicator that can evaluate actual liver lesion for early stages of viral hepatitis, nonalcoholic fatty liver disease (NAFLD), and cirrhosis. Aim of this study was to investigate if albumin binding function could better reflect liver function in these liver diseases. Methods. An observational study was performed on 193 patients with early NAFLD, viral hepatitis, and cirrhosis. Cirrhosis patients were separated according to Child-Pugh score into A, B, and C subgroup. Albumin metal ion binding capacity (Ischemia-modified albumin transformed, IMAT) and fatty acid binding capacity (total binding sites, TBS) were detected. Results. Both IMAT and TBS were significantly decreased in patients with NAFLD and early hepatitis. In hepatitis group, they declined prior to changes of liver enzymes. IMAT was significantly higher in cirrhosis Child-Pugh class A group than hepatitis patients and decreased in Child-Pugh class B and class C patients. Both IMAT/albumin and TBS/albumin decreased significantly in hepatitis and NAFLD group patients. Conclusions. This is the first study to discover changes of albumin metal ion and fatty acid binding capacities prior to conventional biomarkers for liver damage in early stage of liver diseases. They may become potential earliest sensitive indicators for liver function evaluation.http://dx.doi.org/10.1155/2016/5120760 |
| spellingShingle | Penglei Ge Huayu Yang Jingfen Lu Wenjun Liao Shunda Du Yingli Xu Haifeng Xu Haitao Zhao Xin Lu Xinting Sang Shouxian Zhong Jiefu Huang Yilei Mao Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage Gastroenterology Research and Practice |
| title | Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage |
| title_full | Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage |
| title_fullStr | Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage |
| title_full_unstemmed | Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage |
| title_short | Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage |
| title_sort | albumin binding function the potential earliest indicator for liver function damage |
| url | http://dx.doi.org/10.1155/2016/5120760 |
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