Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models
Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of γ-...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/816450 |
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| author | João Carlos C. Queiroz Ângelo R. Antoniolli Lucindo J. Quintans-Júnior Renan G. Brito Rosana S. S. Barreto Emmanoel V. Costa Thanany B. da Silva Ana Paula Nascimento Prata Waldecy de Lucca Jackson R. G. S. Almeida Julianeli T. Lima Jullyana S. S. Quintans |
| author_facet | João Carlos C. Queiroz Ângelo R. Antoniolli Lucindo J. Quintans-Júnior Renan G. Brito Rosana S. S. Barreto Emmanoel V. Costa Thanany B. da Silva Ana Paula Nascimento Prata Waldecy de Lucca Jackson R. G. S. Almeida Julianeli T. Lima Jullyana S. S. Quintans |
| author_sort | João Carlos C. Queiroz |
| collection | DOAJ |
| description | Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of γ-muurolene (17.78%), δ-cadinene (12.23%), bicyclogermacrene (7.77%), and α-copaene (7.17%) as main compounds. EOX presented a strong antioxidant potential according to the DPPH, TBARS, and nitrite production tests. Additionally, pretreatment with EOX, in mice, also significantly produced (P<0.05 or P<0.001) antinociceptive effect by reduction of nociceptive behavior (in formalin and writhing tests). The EOX showed c-Fos label in the olfactory bulb, piriform cortex, and periaqueductal gray. Acute administration of EOX exhibited a significant (P<0.01 or P<0.001) anti-inflammatory profile in the carrageenan-induced peritonitis and by the carrageenan-induced hindpaw edema tests in mice. Our results provide evidence for the use of X. laevigata by traditional medicine practitioners in the management of pain and inflammatory disorders. |
| format | Article |
| id | doaj-art-a857a0d8eb11427d9f303dc37a2eeccc |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a857a0d8eb11427d9f303dc37a2eeccc2025-02-03T05:52:20ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/816450816450Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental ModelsJoão Carlos C. Queiroz0Ângelo R. Antoniolli1Lucindo J. Quintans-Júnior2Renan G. Brito3Rosana S. S. Barreto4Emmanoel V. Costa5Thanany B. da Silva6Ana Paula Nascimento Prata7Waldecy de Lucca8Jackson R. G. S. Almeida9Julianeli T. Lima10Jullyana S. S. Quintans11Departamento de Fisiologia, Universidade Federal de Sergipe, 49.000-100 São Cristóvão, SE, BrazilDepartamento de Fisiologia, Universidade Federal de Sergipe, 49.000-100 São Cristóvão, SE, BrazilDepartamento de Fisiologia, Universidade Federal de Sergipe, 49.000-100 São Cristóvão, SE, BrazilDepartamento de Fisiologia, Universidade Federal de Sergipe, 49.000-100 São Cristóvão, SE, BrazilDepartamento de Fisiologia, Universidade Federal de Sergipe, 49.000-100 São Cristóvão, SE, BrazilDepartamento de Química, Universidade Federal de Sergipe, 49.000-100 São Cristóvão, SE, BrazilDepartamento de Química, Universidade Federal de Sergipe, 49.000-100 São Cristóvão, SE, BrazilDepartamento de Biologia, Universidade Federal de Sergipe, 49.000-100 São Cristóvão, SE, BrazilDepartamento de Morfologia, Universidade Federal de Sergipe, CEP 49.000-100 São Cristóvão, SE, BrazilColegiado de Ciências Farmacêuticas, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, BrazilColegiado de Ciências Farmacêuticas, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, BrazilDepartamento de Fisiologia, Universidade Federal de Sergipe, 49.000-100 São Cristóvão, SE, BrazilXylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of γ-muurolene (17.78%), δ-cadinene (12.23%), bicyclogermacrene (7.77%), and α-copaene (7.17%) as main compounds. EOX presented a strong antioxidant potential according to the DPPH, TBARS, and nitrite production tests. Additionally, pretreatment with EOX, in mice, also significantly produced (P<0.05 or P<0.001) antinociceptive effect by reduction of nociceptive behavior (in formalin and writhing tests). The EOX showed c-Fos label in the olfactory bulb, piriform cortex, and periaqueductal gray. Acute administration of EOX exhibited a significant (P<0.01 or P<0.001) anti-inflammatory profile in the carrageenan-induced peritonitis and by the carrageenan-induced hindpaw edema tests in mice. Our results provide evidence for the use of X. laevigata by traditional medicine practitioners in the management of pain and inflammatory disorders.http://dx.doi.org/10.1155/2014/816450 |
| spellingShingle | João Carlos C. Queiroz Ângelo R. Antoniolli Lucindo J. Quintans-Júnior Renan G. Brito Rosana S. S. Barreto Emmanoel V. Costa Thanany B. da Silva Ana Paula Nascimento Prata Waldecy de Lucca Jackson R. G. S. Almeida Julianeli T. Lima Jullyana S. S. Quintans Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models The Scientific World Journal |
| title | Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models |
| title_full | Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models |
| title_fullStr | Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models |
| title_full_unstemmed | Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models |
| title_short | Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models |
| title_sort | evaluation of the anti inflammatory and antinociceptive effects of the essential oil from leaves of xylopia laevigata in experimental models |
| url | http://dx.doi.org/10.1155/2014/816450 |
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