Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population
Objectives. The variant rs3828903 within MICB, a nonclassical MHC class I chain-related gene, was detected to contribute to systemic lupus erythematosus (SLE) in a Caucasian population. This study aimed to investigate the association in a northern Han Chinese population. Methods. We recruited 1077 S...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/1343760 |
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| author | Yue-miao Zhang Xu-jie Zhou Fa-juan Cheng Yuan-yuan Qi Ping Hou Ming-hui Zhao Hong Zhang |
| author_facet | Yue-miao Zhang Xu-jie Zhou Fa-juan Cheng Yuan-yuan Qi Ping Hou Ming-hui Zhao Hong Zhang |
| author_sort | Yue-miao Zhang |
| collection | DOAJ |
| description | Objectives. The variant rs3828903 within MICB, a nonclassical MHC class I chain-related gene, was detected to contribute to systemic lupus erythematosus (SLE) in a Caucasian population. This study aimed to investigate the association in a northern Han Chinese population. Methods. We recruited 1077 SLE patients and 793 controls for analysis. rs3828903 was genotyped by TaqMan allele discrimination assay. Using the public databases, its functional annotations and gene differential expression analysis of MICB were evaluated. Results. Significant association between the allele G of rs3828903 and risk susceptibility to SLE was observed after adjusting for sex and age (P=1.87×10-2). In silico analyses predicted a higher affinity to transcription factors for allele G (risk) and cis-expression quantitative trait loci (cis-eQTL) effects of rs3828903 in multiple tissues (P ranging from 2.79×10-6 to 6.27×10-38). Furthermore, higher mRNA expressions of MICB were observed in B cells, monocytes, and renal biopsies from SLE patients compared to controls. Conclusion. An association between rs3828903 and susceptibility to SLE has been detected in a Chinese population. This together with the functional annotations of rs3828903 converts MICB into a main candidate in the pathogenesis of SLE. |
| format | Article |
| id | doaj-art-a85554cf95494b768cfa0b616ac7c288 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-a85554cf95494b768cfa0b616ac7c2882025-02-03T01:33:19ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/13437601343760Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese PopulationYue-miao Zhang0Xu-jie Zhou1Fa-juan Cheng2Yuan-yuan Qi3Ping Hou4Ming-hui Zhao5Hong Zhang6Renal Division, Peking University First Hospital, Beijing 100034, ChinaRenal Division, Peking University First Hospital, Beijing 100034, ChinaRenal Division, Peking University First Hospital, Beijing 100034, ChinaRenal Division, Peking University First Hospital, Beijing 100034, ChinaRenal Division, Peking University First Hospital, Beijing 100034, ChinaRenal Division, Peking University First Hospital, Beijing 100034, ChinaRenal Division, Peking University First Hospital, Beijing 100034, ChinaObjectives. The variant rs3828903 within MICB, a nonclassical MHC class I chain-related gene, was detected to contribute to systemic lupus erythematosus (SLE) in a Caucasian population. This study aimed to investigate the association in a northern Han Chinese population. Methods. We recruited 1077 SLE patients and 793 controls for analysis. rs3828903 was genotyped by TaqMan allele discrimination assay. Using the public databases, its functional annotations and gene differential expression analysis of MICB were evaluated. Results. Significant association between the allele G of rs3828903 and risk susceptibility to SLE was observed after adjusting for sex and age (P=1.87×10-2). In silico analyses predicted a higher affinity to transcription factors for allele G (risk) and cis-expression quantitative trait loci (cis-eQTL) effects of rs3828903 in multiple tissues (P ranging from 2.79×10-6 to 6.27×10-38). Furthermore, higher mRNA expressions of MICB were observed in B cells, monocytes, and renal biopsies from SLE patients compared to controls. Conclusion. An association between rs3828903 and susceptibility to SLE has been detected in a Chinese population. This together with the functional annotations of rs3828903 converts MICB into a main candidate in the pathogenesis of SLE.http://dx.doi.org/10.1155/2016/1343760 |
| spellingShingle | Yue-miao Zhang Xu-jie Zhou Fa-juan Cheng Yuan-yuan Qi Ping Hou Ming-hui Zhao Hong Zhang Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population Journal of Immunology Research |
| title | Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population |
| title_full | Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population |
| title_fullStr | Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population |
| title_full_unstemmed | Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population |
| title_short | Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population |
| title_sort | polymorphism rs3828903 within micb is associated with susceptibility to systemic lupus erythematosus in a northern han chinese population |
| url | http://dx.doi.org/10.1155/2016/1343760 |
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