CRISPR/Cas13-Mediated Inhibition of EBNA1 for Suppression of Epstein–Barr Virus Transcripts and DNA Load in Nasopharyngeal Carcinoma Cells

CRISPR/Cas13-Mediated Inhibition of EBNA1 for Suppression of Epstein–Barr Virus Transcripts and DNA Load in Nasopharyngeal Carcinoma Cells

Epstein–Barr virus (EBV), a double-stranded DNA virus, is implicated in nasopharyngeal carcinoma (NPC), with particularly high incidence in regions such as southern China and Hong Kong. Although NPC is typically treated with radio- and chemotherapy, outcomes remain poor for advanced-stage diagnoses,...

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Bibliographic Details
Main Authors: Lin Lin, Wai-Yin Lui, Chon Phin Ong, Mabel Yin-Chun Yau, Dong-Yan Jin, Kit-San Yuen
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Viruses
Subjects:
Epstein–Barr virus
nasopharyngeal carcinoma
CRISPR/Cas13
EBNA1 inhibition
Online Access:https://www.mdpi.com/1999-4915/17/7/899
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