Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

Diabetic macrovascular disease is one of the most morbid and deadly complications of diabetes. Endothelial dysfunction plays a key role in diabetic macrovascular complications and endothelial cell apoptosis is one of the key indicators of endothelial dysfunction. Methylglyoxal (MGO), a highly reacti...

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Main Authors: Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:FEBS Open Bio
Subjects:
acacetin
calcium homeostasis
diabetic vascular diseases
endoplasmic reticulum stress
endothelial dysfunction
HUVECs apoptosis
Online Access:https://doi.org/10.1002/2211-5463.70004
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https://doi.org/10.1002/2211-5463.70004

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