Mantle Cell Lymphoma in the Thyroid: A Rare Presentation
Background. While 2% of all extranodal Non-Hodgkin Lymphomas present in the thyroid, there exists insufficient data to describe the incidence of mantle cell lymphoma in the thyroid. A case series of 1400 patients revealed that <1% of thyroid lymphomas may be MCL; hence better understanding of the...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2017/6749801 |
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| author | Uzma Mohammad Siddiqui Sarika N. Rao Pallavi Kanwar Galera Nahida Islam Mira S. Torres |
| author_facet | Uzma Mohammad Siddiqui Sarika N. Rao Pallavi Kanwar Galera Nahida Islam Mira S. Torres |
| author_sort | Uzma Mohammad Siddiqui |
| collection | DOAJ |
| description | Background. While 2% of all extranodal Non-Hodgkin Lymphomas present in the thyroid, there exists insufficient data to describe the incidence of mantle cell lymphoma in the thyroid. A case series of 1400 patients revealed that <1% of thyroid lymphomas may be MCL; hence better understanding of the disease course is essential. Patient Findings. A 65-year-old female was referred for a multinodular goiter. Multiple fine needle aspirations from the dominant right nodule were consistent with Hashimoto’s thyroiditis and flow cytometry was negative. Due to progressing dysphagia, she underwent total thyroidectomy. Summary. Pathology revealed MCL with mantle zone growth pattern in the right thyroid. Flow cytometry showed monoclonal B cells comprising 9% of total cells. The Ki-67 index was 10%. She was diagnosed as having stage IIE MCL and offered conservative management by medical oncology, given that she had no B symptoms. Conclusion. Though chemotherapy is the treatment of choice in MCL, a subset of patients with low-grade disease may be observed. As in our patient, mantle zone growth pattern and a Ki-67 index < 10% suggest a favorable prognosis. A diagnosis of primary MCL in the thyroid remains rare and staging modalities as well as treatment options continue to evolve. |
| format | Article |
| id | doaj-art-a845af9c57f3472ba1cc9e23416d5842 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-a845af9c57f3472ba1cc9e23416d58422025-02-03T00:59:19ZengWileyCase Reports in Pathology2090-67812090-679X2017-01-01201710.1155/2017/67498016749801Mantle Cell Lymphoma in the Thyroid: A Rare PresentationUzma Mohammad Siddiqui0Sarika N. Rao1Pallavi Kanwar Galera2Nahida Islam3Mira S. Torres4Division of Endocrinology, University of Massachusetts Medical School, 55 Lake Avenue N., Worcester, MA 01655, USASection of Endocrinology, MedStar Washington Hospital Center, 110 Irving St NW, Suite 2A-72, Washington, DC 20010, USADepartment of Pathology, University of Massachusetts Medical School, Biotech 3, 1 Innovation Drive, Worcester, MA, USADivision of Hematology and Oncology, University of Massachusetts Medical School, 55 Lake Avenue N., Worcester, MA 01655, USADivision of Endocrinology, University of Massachusetts Medical School, 55 Lake Avenue N., Worcester, MA 01655, USABackground. While 2% of all extranodal Non-Hodgkin Lymphomas present in the thyroid, there exists insufficient data to describe the incidence of mantle cell lymphoma in the thyroid. A case series of 1400 patients revealed that <1% of thyroid lymphomas may be MCL; hence better understanding of the disease course is essential. Patient Findings. A 65-year-old female was referred for a multinodular goiter. Multiple fine needle aspirations from the dominant right nodule were consistent with Hashimoto’s thyroiditis and flow cytometry was negative. Due to progressing dysphagia, she underwent total thyroidectomy. Summary. Pathology revealed MCL with mantle zone growth pattern in the right thyroid. Flow cytometry showed monoclonal B cells comprising 9% of total cells. The Ki-67 index was 10%. She was diagnosed as having stage IIE MCL and offered conservative management by medical oncology, given that she had no B symptoms. Conclusion. Though chemotherapy is the treatment of choice in MCL, a subset of patients with low-grade disease may be observed. As in our patient, mantle zone growth pattern and a Ki-67 index < 10% suggest a favorable prognosis. A diagnosis of primary MCL in the thyroid remains rare and staging modalities as well as treatment options continue to evolve.http://dx.doi.org/10.1155/2017/6749801 |
| spellingShingle | Uzma Mohammad Siddiqui Sarika N. Rao Pallavi Kanwar Galera Nahida Islam Mira S. Torres Mantle Cell Lymphoma in the Thyroid: A Rare Presentation Case Reports in Pathology |
| title | Mantle Cell Lymphoma in the Thyroid: A Rare Presentation |
| title_full | Mantle Cell Lymphoma in the Thyroid: A Rare Presentation |
| title_fullStr | Mantle Cell Lymphoma in the Thyroid: A Rare Presentation |
| title_full_unstemmed | Mantle Cell Lymphoma in the Thyroid: A Rare Presentation |
| title_short | Mantle Cell Lymphoma in the Thyroid: A Rare Presentation |
| title_sort | mantle cell lymphoma in the thyroid a rare presentation |
| url | http://dx.doi.org/10.1155/2017/6749801 |
| work_keys_str_mv | AT uzmamohammadsiddiqui mantlecelllymphomainthethyroidararepresentation AT sarikanrao mantlecelllymphomainthethyroidararepresentation AT pallavikanwargalera mantlecelllymphomainthethyroidararepresentation AT nahidaislam mantlecelllymphomainthethyroidararepresentation AT mirastorres mantlecelllymphomainthethyroidararepresentation |