Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy
In the coming decades, the development of nanocarriers (NCs) for targeted drug delivery will mark a significant advance in the field of pharmacology. NCs can improve drug solubility, ensure precise distribution, and enable passage across biological barriers. Despite these potential advantages, the i...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2025-01-01
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| Series: | Beilstein Journal of Nanotechnology |
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| Online Access: | https://doi.org/10.3762/bjnano.16.10 |
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| author | Naths Grazia Sukubo Paolo Bigini Annalisa Morelli |
| author_facet | Naths Grazia Sukubo Paolo Bigini Annalisa Morelli |
| author_sort | Naths Grazia Sukubo |
| collection | DOAJ |
| description | In the coming decades, the development of nanocarriers (NCs) for targeted drug delivery will mark a significant advance in the field of pharmacology. NCs can improve drug solubility, ensure precise distribution, and enable passage across biological barriers. Despite these potential advantages, the interaction with many biological matrices, particularly with existing macrophages, must be considered. In this review, we will explore the dual role of macrophages in NC delivery, highlighting their physiological functions, the challenges posed by the mononuclear phagocyte system, and innovative strategies to exploit macrophage interactions for therapeutic advantage. Recent advancements in treating liver and lung diseases, particularly focusing on macrophage polarization and RNA-based therapies, have highlighted the potential developments in macrophage–NC interaction. Furthermore, we will delve into the intriguing potential of nanomedicine in neurology and traumatology, associated with macrophage interaction, and the exciting possibilities it holds for the future. |
| format | Article |
| id | doaj-art-a83f0181556e4c3f929533a003482c2c |
| institution | Kabale University |
| issn | 2190-4286 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Nanotechnology |
| spelling | doaj-art-a83f0181556e4c3f929533a003482c2c2025-02-03T09:10:12ZengBeilstein-InstitutBeilstein Journal of Nanotechnology2190-42862025-01-011619711810.3762/bjnano.16.102190-4286-16-10Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategyNaths Grazia Sukubo0Paolo Bigini1Annalisa Morelli2School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, Monza, Italy Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano, Italy Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano, Italy In the coming decades, the development of nanocarriers (NCs) for targeted drug delivery will mark a significant advance in the field of pharmacology. NCs can improve drug solubility, ensure precise distribution, and enable passage across biological barriers. Despite these potential advantages, the interaction with many biological matrices, particularly with existing macrophages, must be considered. In this review, we will explore the dual role of macrophages in NC delivery, highlighting their physiological functions, the challenges posed by the mononuclear phagocyte system, and innovative strategies to exploit macrophage interactions for therapeutic advantage. Recent advancements in treating liver and lung diseases, particularly focusing on macrophage polarization and RNA-based therapies, have highlighted the potential developments in macrophage–NC interaction. Furthermore, we will delve into the intriguing potential of nanomedicine in neurology and traumatology, associated with macrophage interaction, and the exciting possibilities it holds for the future.https://doi.org/10.3762/bjnano.16.10drug deliverymacrophagesnanomedicinepolarizationrna-based therapies |
| spellingShingle | Naths Grazia Sukubo Paolo Bigini Annalisa Morelli Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy Beilstein Journal of Nanotechnology drug delivery macrophages nanomedicine polarization rna-based therapies |
| title | Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy |
| title_full | Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy |
| title_fullStr | Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy |
| title_full_unstemmed | Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy |
| title_short | Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy |
| title_sort | nanocarriers and macrophage interaction from a potential hurdle to an alternative therapeutic strategy |
| topic | drug delivery macrophages nanomedicine polarization rna-based therapies |
| url | https://doi.org/10.3762/bjnano.16.10 |
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