Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancy
Abstract Recurrent spontaneous abortion (RSA), characterized by the loss of two or more pregnancies, impacts approximately 1–2% of couples and poses a significant challenge for individuals of childbearing age. The precise mechanisms underlying RSA remain incompletely understood. Concurrently, the gl...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Reproductive Biology and Endocrinology |
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| Online Access: | https://doi.org/10.1186/s12958-024-01326-3 |
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| author | Rui-Qi Wang Zhi-Min Deng Gan-Tao Chen Fang-Fang Dai Liang-Bin Xia |
| author_facet | Rui-Qi Wang Zhi-Min Deng Gan-Tao Chen Fang-Fang Dai Liang-Bin Xia |
| author_sort | Rui-Qi Wang |
| collection | DOAJ |
| description | Abstract Recurrent spontaneous abortion (RSA), characterized by the loss of two or more pregnancies, impacts approximately 1–2% of couples and poses a significant challenge for individuals of childbearing age. The precise mechanisms underlying RSA remain incompletely understood. Concurrently, the global prevalence of obesity is on the rise, with obesity being closely associated with female reproductive disorders and infertility. This study initially examines the pathways through which obesity contributes to RSA, encompassing factors such as embryonic euploid miscarriage, endometrial development, immune function, among others. Furthermore, adipokines and the fat mass and obesity-related (FTO) are identified as potential contributors to RSA. The study also explores the enhancement of pregnancy outcomes through various weight management strategies, with a particular focus on the roles of dietary interventions, physical activity, and weight control during pregnancy. Obesity is closely related to RSA in multiple aspects. Additional clinical prospective and experimental studies are required to explore its precise pathogenesis. Through this review, we aim to provide strategies for improvement and treatment approaches for RSA related to obesity. Through this review, we suggest potential clinical management strategies and research avenues aimed at offering enhancements and therapeutic insights for miscarriages linked to obesity and its associated risk factors. |
| format | Article |
| id | doaj-art-a8379453eb7848889ede2c6769ccced3 |
| institution | Kabale University |
| issn | 1477-7827 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj-art-a8379453eb7848889ede2c6769ccced32025-01-26T12:58:02ZengBMCReproductive Biology and Endocrinology1477-78272025-01-0123111910.1186/s12958-024-01326-3Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancyRui-Qi Wang0Zhi-Min Deng1Gan-Tao Chen2Fang-Fang Dai3Liang-Bin Xia4Department of Gynecology, Renmin Hospital of Wuhan UniversityDepartment of Gynecology, Renmin Hospital of Wuhan UniversityDepartment of Gastroenterology, Renmin Hospital of Wuhan UniversityDepartment of Gynecology, Renmin Hospital of Wuhan UniversityDepartment of Gynecology, Renmin Hospital of Wuhan UniversityAbstract Recurrent spontaneous abortion (RSA), characterized by the loss of two or more pregnancies, impacts approximately 1–2% of couples and poses a significant challenge for individuals of childbearing age. The precise mechanisms underlying RSA remain incompletely understood. Concurrently, the global prevalence of obesity is on the rise, with obesity being closely associated with female reproductive disorders and infertility. This study initially examines the pathways through which obesity contributes to RSA, encompassing factors such as embryonic euploid miscarriage, endometrial development, immune function, among others. Furthermore, adipokines and the fat mass and obesity-related (FTO) are identified as potential contributors to RSA. The study also explores the enhancement of pregnancy outcomes through various weight management strategies, with a particular focus on the roles of dietary interventions, physical activity, and weight control during pregnancy. Obesity is closely related to RSA in multiple aspects. Additional clinical prospective and experimental studies are required to explore its precise pathogenesis. Through this review, we aim to provide strategies for improvement and treatment approaches for RSA related to obesity. Through this review, we suggest potential clinical management strategies and research avenues aimed at offering enhancements and therapeutic insights for miscarriages linked to obesity and its associated risk factors.https://doi.org/10.1186/s12958-024-01326-3ObesityRecurrent spontaneous abortionEndometriumOocytesImmune imbalanceBody mass index |
| spellingShingle | Rui-Qi Wang Zhi-Min Deng Gan-Tao Chen Fang-Fang Dai Liang-Bin Xia Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancy Reproductive Biology and Endocrinology Obesity Recurrent spontaneous abortion Endometrium Oocytes Immune imbalance Body mass index |
| title | Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancy |
| title_full | Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancy |
| title_fullStr | Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancy |
| title_full_unstemmed | Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancy |
| title_short | Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancy |
| title_sort | obesity and recurrent spontaneous abortion the crucial role of weight management in pregnancy |
| topic | Obesity Recurrent spontaneous abortion Endometrium Oocytes Immune imbalance Body mass index |
| url | https://doi.org/10.1186/s12958-024-01326-3 |
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