Metabolic Syndrome in People Living with Human Immunodeficiency Virus: An Assessment of the Prevalence and the Agreement between Diagnostic Criteria
Objectives. We determined metabolic syndrome (MetS) prevalence and assessed the agreement between different diagnostic criteria in HIV-infected South Africans. Method. A random sample included 748 HIV-infected adult patients (79% women) across 17 HIV healthcare facilities in the Western Cape Provinc...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/1613657 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556351190990848 |
|---|---|
| author | Kim Anh Nguyen Nasheeta Peer Anniza de Villiers Barbara Mukasa Tandi E. Matsha Edward J. Mills Andre Pascal Kengne |
| author_facet | Kim Anh Nguyen Nasheeta Peer Anniza de Villiers Barbara Mukasa Tandi E. Matsha Edward J. Mills Andre Pascal Kengne |
| author_sort | Kim Anh Nguyen |
| collection | DOAJ |
| description | Objectives. We determined metabolic syndrome (MetS) prevalence and assessed the agreement between different diagnostic criteria in HIV-infected South Africans. Method. A random sample included 748 HIV-infected adult patients (79% women) across 17 HIV healthcare facilities in the Western Cape Province. MetS was defined using the Joint Interim Statement (JIS 2009), International Diabetes Federation (IDF 2005), and Adult Treatment Panel III (ATPIII 2005) criteria. Results. Median values were 38 years (age), 5 years (diagnosed HIV duration), and 392 cells/mm3 (CD4 count), and 93% of the participants were on antiretroviral therapy (ART). MetS prevalence was 28.2% (95%CI: 25–31.4), 26.5% (23.3–29.6), and 24.1% (21–27.1) by the JIS, IDF, and ATPIII 2005 criteria, respectively. Prevalence was always higher in women than in men (all p<0.001), in participants with longer duration of diagnosed HIV (all p≤0.003), and in ART users not receiving 1st-line regimens (all p≤0.039). The agreement among the three criteria was very good overall and in most subgroups (all kappa≥0.81). Conclusions. The three most popular diagnostic criteria yielded similarly high MetS prevalence in this relatively young population receiving care for HIV infection. Very good levels of agreement between criteria are unaffected by some HIV-specific features highlighting the likely comparable diagnostic utility of those criteria in routine HIV care settings. |
| format | Article |
| id | doaj-art-a828db42317f4a2db6dbd12f034dbea1 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-a828db42317f4a2db6dbd12f034dbea12025-02-03T05:45:40ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/16136571613657Metabolic Syndrome in People Living with Human Immunodeficiency Virus: An Assessment of the Prevalence and the Agreement between Diagnostic CriteriaKim Anh Nguyen0Nasheeta Peer1Anniza de Villiers2Barbara Mukasa3Tandi E. Matsha4Edward J. Mills5Andre Pascal Kengne6Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town 7505, South AfricaNon-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town 7505, South AfricaNon-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town 7505, South AfricaUnited Nations Population Fund (UNFPA), Mildmay Uganda, P.O. Box 24985, Lweza, UgandaDepartment of Biomedical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, Cape Town 7535, South AfricaGlobal Evaluation Science, Vancouver, BC, V6H 3X4, CanadaNon-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town 7505, South AfricaObjectives. We determined metabolic syndrome (MetS) prevalence and assessed the agreement between different diagnostic criteria in HIV-infected South Africans. Method. A random sample included 748 HIV-infected adult patients (79% women) across 17 HIV healthcare facilities in the Western Cape Province. MetS was defined using the Joint Interim Statement (JIS 2009), International Diabetes Federation (IDF 2005), and Adult Treatment Panel III (ATPIII 2005) criteria. Results. Median values were 38 years (age), 5 years (diagnosed HIV duration), and 392 cells/mm3 (CD4 count), and 93% of the participants were on antiretroviral therapy (ART). MetS prevalence was 28.2% (95%CI: 25–31.4), 26.5% (23.3–29.6), and 24.1% (21–27.1) by the JIS, IDF, and ATPIII 2005 criteria, respectively. Prevalence was always higher in women than in men (all p<0.001), in participants with longer duration of diagnosed HIV (all p≤0.003), and in ART users not receiving 1st-line regimens (all p≤0.039). The agreement among the three criteria was very good overall and in most subgroups (all kappa≥0.81). Conclusions. The three most popular diagnostic criteria yielded similarly high MetS prevalence in this relatively young population receiving care for HIV infection. Very good levels of agreement between criteria are unaffected by some HIV-specific features highlighting the likely comparable diagnostic utility of those criteria in routine HIV care settings.http://dx.doi.org/10.1155/2017/1613657 |
| spellingShingle | Kim Anh Nguyen Nasheeta Peer Anniza de Villiers Barbara Mukasa Tandi E. Matsha Edward J. Mills Andre Pascal Kengne Metabolic Syndrome in People Living with Human Immunodeficiency Virus: An Assessment of the Prevalence and the Agreement between Diagnostic Criteria International Journal of Endocrinology |
| title | Metabolic Syndrome in People Living with Human Immunodeficiency Virus: An Assessment of the Prevalence and the Agreement between Diagnostic Criteria |
| title_full | Metabolic Syndrome in People Living with Human Immunodeficiency Virus: An Assessment of the Prevalence and the Agreement between Diagnostic Criteria |
| title_fullStr | Metabolic Syndrome in People Living with Human Immunodeficiency Virus: An Assessment of the Prevalence and the Agreement between Diagnostic Criteria |
| title_full_unstemmed | Metabolic Syndrome in People Living with Human Immunodeficiency Virus: An Assessment of the Prevalence and the Agreement between Diagnostic Criteria |
| title_short | Metabolic Syndrome in People Living with Human Immunodeficiency Virus: An Assessment of the Prevalence and the Agreement between Diagnostic Criteria |
| title_sort | metabolic syndrome in people living with human immunodeficiency virus an assessment of the prevalence and the agreement between diagnostic criteria |
| url | http://dx.doi.org/10.1155/2017/1613657 |
| work_keys_str_mv | AT kimanhnguyen metabolicsyndromeinpeoplelivingwithhumanimmunodeficiencyvirusanassessmentoftheprevalenceandtheagreementbetweendiagnosticcriteria AT nasheetapeer metabolicsyndromeinpeoplelivingwithhumanimmunodeficiencyvirusanassessmentoftheprevalenceandtheagreementbetweendiagnosticcriteria AT annizadevilliers metabolicsyndromeinpeoplelivingwithhumanimmunodeficiencyvirusanassessmentoftheprevalenceandtheagreementbetweendiagnosticcriteria AT barbaramukasa metabolicsyndromeinpeoplelivingwithhumanimmunodeficiencyvirusanassessmentoftheprevalenceandtheagreementbetweendiagnosticcriteria AT tandiematsha metabolicsyndromeinpeoplelivingwithhumanimmunodeficiencyvirusanassessmentoftheprevalenceandtheagreementbetweendiagnosticcriteria AT edwardjmills metabolicsyndromeinpeoplelivingwithhumanimmunodeficiencyvirusanassessmentoftheprevalenceandtheagreementbetweendiagnosticcriteria AT andrepascalkengne metabolicsyndromeinpeoplelivingwithhumanimmunodeficiencyvirusanassessmentoftheprevalenceandtheagreementbetweendiagnosticcriteria |