A review on mechanisms of action of bioactive peptides against glucose intolerance and insulin resistance
Insulin resistance leads to impaired glucose metabolism by disrupting both insulin secretion and sensitivity. Insulin resistance plays a key role in the pathophysiology of type 2 diabetes and metabolic syndrome. Reviews on the mechanisms of action of bioactive peptides on glucose homeostasis and ins...
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Tsinghua University Press
2022-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022000842 |
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| author | Forough Jahandideh Jianping Wu |
| author_facet | Forough Jahandideh Jianping Wu |
| author_sort | Forough Jahandideh |
| collection | DOAJ |
| description | Insulin resistance leads to impaired glucose metabolism by disrupting both insulin secretion and sensitivity. Insulin resistance plays a key role in the pathophysiology of type 2 diabetes and metabolic syndrome. Reviews on the mechanisms of action of bioactive peptides on glucose homeostasis and insulin resistance are scarce. The recent discoveries of pathways and target cells in the management of glucose and energy metabolism have opened up new opportunities for identification of novel bioactive peptides on enhancing adipocyte differentiation and insulin signaling, glucose uptake, cholecystokinin receptor expression and activation, as well as insulin mimetics and incretin stimulants. Examples of food-derived bioactive peptides with glucoregulatory properties include Trp-Glu-Lys-Ala-Phe-Lys-Asp-Glu-Asp (WEKAFKDED), Gln-Ala-Met-Pro-Phe-Arg-Val-Thr-Glu-Gln-Glu (QAMPFRVTEQE), Glu-Arg-Tyr-Pro-Ile-Leu (ERKPIL), Val-Phe-Lys-Gly-Leu (VFKGL), Phe-Leu-Val (FLV), Val-Pro-Pro (VPP), Ile-Arg-Trp (IRW), Ala-Lys-Ser-Pro-Leu-Phe (AKSPLF), Ala-Thr-Gln-Pro-Leu-Phe (ATNPLF), Phe-Glu-Glu-Leu-Gln (FEELN), Leu-Ser-Val-Ser-Val-Leu (LSVSVL), Val-Arg-Ileu-Arg-Leu-Leu-Gln-Arg-Phe-Asn-Lys-Arg-Ser (VRIRLLQRFNKRS), and Ala-Gly-Phe-Ala-Gly-Asp-Asp-Ala-Pro-Arg (AGFAGDDAPR). However, as yet, clinical evidence on the efficacy of such bioactive peptides is rare but is inevitable to establish their applications against glucose intolerance and insulin resistance. |
| format | Article |
| id | doaj-art-a82430c553674fc1aaba9670a4aa4b07 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-a82430c553674fc1aaba9670a4aa4b072025-02-03T03:59:54ZengTsinghua University PressFood Science and Human Wellness2213-45302022-11-0111614411454A review on mechanisms of action of bioactive peptides against glucose intolerance and insulin resistanceForough Jahandideh0Jianping Wu1Department of Agricultural, Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, AB, T6G 2P5, Canada; Cardiovascular Research Centre, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, T6G 2S2, CanadaDepartment of Agricultural, Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, AB, T6G 2P5, Canada; Cardiovascular Research Centre, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, T6G 2S2, Canada; Correspondence.Insulin resistance leads to impaired glucose metabolism by disrupting both insulin secretion and sensitivity. Insulin resistance plays a key role in the pathophysiology of type 2 diabetes and metabolic syndrome. Reviews on the mechanisms of action of bioactive peptides on glucose homeostasis and insulin resistance are scarce. The recent discoveries of pathways and target cells in the management of glucose and energy metabolism have opened up new opportunities for identification of novel bioactive peptides on enhancing adipocyte differentiation and insulin signaling, glucose uptake, cholecystokinin receptor expression and activation, as well as insulin mimetics and incretin stimulants. Examples of food-derived bioactive peptides with glucoregulatory properties include Trp-Glu-Lys-Ala-Phe-Lys-Asp-Glu-Asp (WEKAFKDED), Gln-Ala-Met-Pro-Phe-Arg-Val-Thr-Glu-Gln-Glu (QAMPFRVTEQE), Glu-Arg-Tyr-Pro-Ile-Leu (ERKPIL), Val-Phe-Lys-Gly-Leu (VFKGL), Phe-Leu-Val (FLV), Val-Pro-Pro (VPP), Ile-Arg-Trp (IRW), Ala-Lys-Ser-Pro-Leu-Phe (AKSPLF), Ala-Thr-Gln-Pro-Leu-Phe (ATNPLF), Phe-Glu-Glu-Leu-Gln (FEELN), Leu-Ser-Val-Ser-Val-Leu (LSVSVL), Val-Arg-Ileu-Arg-Leu-Leu-Gln-Arg-Phe-Asn-Lys-Arg-Ser (VRIRLLQRFNKRS), and Ala-Gly-Phe-Ala-Gly-Asp-Asp-Ala-Pro-Arg (AGFAGDDAPR). However, as yet, clinical evidence on the efficacy of such bioactive peptides is rare but is inevitable to establish their applications against glucose intolerance and insulin resistance.http://www.sciencedirect.com/science/article/pii/S2213453022000842Adipose tissueBioactive peptidesGlucose homeostasisInsulin resistanceMetabolic syndrome |
| spellingShingle | Forough Jahandideh Jianping Wu A review on mechanisms of action of bioactive peptides against glucose intolerance and insulin resistance Food Science and Human Wellness Adipose tissue Bioactive peptides Glucose homeostasis Insulin resistance Metabolic syndrome |
| title | A review on mechanisms of action of bioactive peptides against glucose intolerance and insulin resistance |
| title_full | A review on mechanisms of action of bioactive peptides against glucose intolerance and insulin resistance |
| title_fullStr | A review on mechanisms of action of bioactive peptides against glucose intolerance and insulin resistance |
| title_full_unstemmed | A review on mechanisms of action of bioactive peptides against glucose intolerance and insulin resistance |
| title_short | A review on mechanisms of action of bioactive peptides against glucose intolerance and insulin resistance |
| title_sort | review on mechanisms of action of bioactive peptides against glucose intolerance and insulin resistance |
| topic | Adipose tissue Bioactive peptides Glucose homeostasis Insulin resistance Metabolic syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022000842 |
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