Cell division cycle protein 42-driven activation of the MKK3/6-p38 signaling pathway participates in cardiac remodeling in mice

Cell division cycle protein 42-driven activation of the MKK3/6-p38 signaling pathway participates in cardiac remodeling in mice

Abstract Cell division cycle protein 42 (Cdc42) is a member of the Rho GTPase subfamily that serves as a signal mediating factor in cell cycle division, cytoskeleton arrangement, cell polarization, membrane trafficking and signal transduction. However, the role of Cdc42 in cardiac remodeling, includ...

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Main Authors: Ke Wen, Lin Xie, Quan-Wen Liu, Guan-Hui Yu, Xu-Hui Qiao, Yu-Chun Huang, Lu Wang, Xin Li, Li-Dan Wen, Xiao-Lei Wang, Jing He, Xin-Yu Xiao, Xiao-Xiao Zhao, Ling-Fang Wang, Hong-Bo Xin, Ke-Yu Deng
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Cellular and Molecular Life Sciences
Subjects:
Cardiac function
Cardiomyocyte hypertrophy
Apoptosis
Inflammation
Online Access:https://doi.org/10.1007/s00018-025-05743-4
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https://doi.org/10.1007/s00018-025-05743-4

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