Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology
Diosgenin, a steroidal sapogenin, occurs abundantly in plants such as Dioscorea alata, Smilax China, and Trigonella foenum graecum. This bioactive phytochemical not only is used as an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry, but has r...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/4156293 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545390706032640 |
|---|---|
| author | Mafalda Jesus Ana P. J. Martins Eugenia Gallardo Samuel Silvestre |
| author_facet | Mafalda Jesus Ana P. J. Martins Eugenia Gallardo Samuel Silvestre |
| author_sort | Mafalda Jesus |
| collection | DOAJ |
| description | Diosgenin, a steroidal sapogenin, occurs abundantly in plants such as Dioscorea alata, Smilax China, and Trigonella foenum graecum. This bioactive phytochemical not only is used as an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry, but has revealed also high potential and interest in the treatment of various types of disorders such as cancer, hypercholesterolemia, inflammation, and several types of infections. Due to its pharmacological and industrial importance, several extraction and analytical procedures have been developed and applied over the years to isolate, detect, and quantify diosgenin, not only in its natural sources and pharmaceutical compositions, but also in animal matrices for pharmacodynamic, pharmacokinetic, and toxicological studies. Within these, HPLC technique coupled to different detectors is the most commonly analytical procedure described for this compound. However, other alternative methods were also published. Thus, the present review aims to provide collective information on the most recent pharmacological data on diosgenin and on the most relevant analytical techniques used to isolate, detect, and quantify this compound as well. |
| format | Article |
| id | doaj-art-a81fa8de7741494db8276b540a5b408a |
| institution | Kabale University |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-a81fa8de7741494db8276b540a5b408a2025-02-03T07:25:57ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732016-01-01201610.1155/2016/41562934156293Diosgenin: Recent Highlights on Pharmacology and Analytical MethodologyMafalda Jesus0Ana P. J. Martins1Eugenia Gallardo2Samuel Silvestre3CICS-UBI, Health Sciences Research Centre, Universidade da Beira Interior, Covilhã, PortugalCICS-UBI, Health Sciences Research Centre, Universidade da Beira Interior, Covilhã, PortugalCICS-UBI, Health Sciences Research Centre, Universidade da Beira Interior, Covilhã, PortugalCICS-UBI, Health Sciences Research Centre, Universidade da Beira Interior, Covilhã, PortugalDiosgenin, a steroidal sapogenin, occurs abundantly in plants such as Dioscorea alata, Smilax China, and Trigonella foenum graecum. This bioactive phytochemical not only is used as an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry, but has revealed also high potential and interest in the treatment of various types of disorders such as cancer, hypercholesterolemia, inflammation, and several types of infections. Due to its pharmacological and industrial importance, several extraction and analytical procedures have been developed and applied over the years to isolate, detect, and quantify diosgenin, not only in its natural sources and pharmaceutical compositions, but also in animal matrices for pharmacodynamic, pharmacokinetic, and toxicological studies. Within these, HPLC technique coupled to different detectors is the most commonly analytical procedure described for this compound. However, other alternative methods were also published. Thus, the present review aims to provide collective information on the most recent pharmacological data on diosgenin and on the most relevant analytical techniques used to isolate, detect, and quantify this compound as well.http://dx.doi.org/10.1155/2016/4156293 |
| spellingShingle | Mafalda Jesus Ana P. J. Martins Eugenia Gallardo Samuel Silvestre Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology Journal of Analytical Methods in Chemistry |
| title | Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology |
| title_full | Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology |
| title_fullStr | Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology |
| title_full_unstemmed | Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology |
| title_short | Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology |
| title_sort | diosgenin recent highlights on pharmacology and analytical methodology |
| url | http://dx.doi.org/10.1155/2016/4156293 |
| work_keys_str_mv | AT mafaldajesus diosgeninrecenthighlightsonpharmacologyandanalyticalmethodology AT anapjmartins diosgeninrecenthighlightsonpharmacologyandanalyticalmethodology AT eugeniagallardo diosgeninrecenthighlightsonpharmacologyandanalyticalmethodology AT samuelsilvestre diosgeninrecenthighlightsonpharmacologyandanalyticalmethodology |