Effect of ceftriaxone on blood pressure, respiration and its analgesic and antipyretic activities
<b>Aim:</b> The aim of this study was to determine the effect of ceftriaxone on blood pressure and respiration in dog. In addition, analgesic and antipyretic activities of ceftriaxone were investigated in mice and rats.<p> <b>Materials and Methods:</b> Effect of differe...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=463 |
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| Summary: | <b>Aim:</b> The aim of this study was to determine the effect of
ceftriaxone on blood pressure and respiration in dog. In
addition, analgesic and antipyretic activities of ceftriaxone
were investigated in mice and rats.<p>
<b>Materials and Methods:</b> Effect of different doses of ceftriaxone
(26.66, 53.33, 106.66 mg/kg, IV) on blood pressure
and respiration rate were determined in anesthetized dogs.
Analgesic and antipyretic activities of two different doses of
ceftriaxone were investigated in mice and rats, respectively.<p>
<b>Results:</b> Ceftriaxone had no effect on blood pressure and
rate of respiration in anesthetized dogs. However, ceftriaxone
(260 and 520 mg/kg) had a significant analgesic effect
for four hours and had a significant antipyretic effect at 2.5
and 1.5 hours at doses of 180 and 360 mg/kg, respectively.<p>
<b>Conclusion:</b> Ceftriaxone is preferable in bacterial infections
or feverish conditions owing to its antibacterial, antipyretic
and analgesic activities. |
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| ISSN: | 1309-6958 2146-1953 |