A Case of Male Osteoporosis: A 37-Year-Old Man with Multiple Vertebral Compression Fractures
While the contributing role of testosterone to bone health is rather modest compared to other factors such as estradiol levels, male hypogonadism is associated with low bone mass and fragility fractures. Along with stimulating physical puberty by achieving virilization and a normal muscle mass and i...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/6328524 |
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| author | Suhaib Radi Andrew C. Karaplis |
| author_facet | Suhaib Radi Andrew C. Karaplis |
| author_sort | Suhaib Radi |
| collection | DOAJ |
| description | While the contributing role of testosterone to bone health is rather modest compared to other factors such as estradiol levels, male hypogonadism is associated with low bone mass and fragility fractures. Along with stimulating physical puberty by achieving virilization and a normal muscle mass and improving psychosocial wellbeing, the goals of testosterone replacement therapy in male hypogonadism also include attainment of age-specific bone mineral density. We report on a 37-year-old man who presented with multiple vertebral compression fractures several years following termination of testosterone replacement therapy for presumed constitutional delay in growth and puberty. Here, we discuss the management of congenital hypogonadotropic hypogonadism with hyposmia (Kallmann syndrome), with which the patient was ultimately diagnosed, the role of androgens in the acquisition of bone mass during puberty and its maintenance thereafter, and outline specific management strategies for patients with hypogonadism and high risk for fragility fractures. |
| format | Article |
| id | doaj-art-a8127f4b7d3f4e3c9ad0b30e0751a8fd |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-a8127f4b7d3f4e3c9ad0b30e0751a8fd2025-02-03T01:26:13ZengWileyCase Reports in Endocrinology2090-65012090-651X2017-01-01201710.1155/2017/63285246328524A Case of Male Osteoporosis: A 37-Year-Old Man with Multiple Vertebral Compression FracturesSuhaib Radi0Andrew C. Karaplis1Division of Endocrinology, Department of Medicine, Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2, CanadaDivision of Endocrinology, Department of Medicine, Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2, CanadaWhile the contributing role of testosterone to bone health is rather modest compared to other factors such as estradiol levels, male hypogonadism is associated with low bone mass and fragility fractures. Along with stimulating physical puberty by achieving virilization and a normal muscle mass and improving psychosocial wellbeing, the goals of testosterone replacement therapy in male hypogonadism also include attainment of age-specific bone mineral density. We report on a 37-year-old man who presented with multiple vertebral compression fractures several years following termination of testosterone replacement therapy for presumed constitutional delay in growth and puberty. Here, we discuss the management of congenital hypogonadotropic hypogonadism with hyposmia (Kallmann syndrome), with which the patient was ultimately diagnosed, the role of androgens in the acquisition of bone mass during puberty and its maintenance thereafter, and outline specific management strategies for patients with hypogonadism and high risk for fragility fractures.http://dx.doi.org/10.1155/2017/6328524 |
| spellingShingle | Suhaib Radi Andrew C. Karaplis A Case of Male Osteoporosis: A 37-Year-Old Man with Multiple Vertebral Compression Fractures Case Reports in Endocrinology |
| title | A Case of Male Osteoporosis: A 37-Year-Old Man with Multiple Vertebral Compression Fractures |
| title_full | A Case of Male Osteoporosis: A 37-Year-Old Man with Multiple Vertebral Compression Fractures |
| title_fullStr | A Case of Male Osteoporosis: A 37-Year-Old Man with Multiple Vertebral Compression Fractures |
| title_full_unstemmed | A Case of Male Osteoporosis: A 37-Year-Old Man with Multiple Vertebral Compression Fractures |
| title_short | A Case of Male Osteoporosis: A 37-Year-Old Man with Multiple Vertebral Compression Fractures |
| title_sort | case of male osteoporosis a 37 year old man with multiple vertebral compression fractures |
| url | http://dx.doi.org/10.1155/2017/6328524 |
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