The Impact of Abnormal Glucose Tolerance and Obesity on Fetal Growth
Objective. Factors linked with insulin resistance were examined for their association with large-for-gestational-age (LGA) infant birth weight and gestational diabetes. Study Design. Data came from a longitudinal cohort study of 2,305 subjects without overt diabetes, analyzed using multinomial logis...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/847674 |
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| _version_ | 1832545802815275008 |
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| author | Erin Graves David J. Hill Susan Evers Kristine Van Aarsen Brie Yama Su Yuan M. Karen Campbell |
| author_facet | Erin Graves David J. Hill Susan Evers Kristine Van Aarsen Brie Yama Su Yuan M. Karen Campbell |
| author_sort | Erin Graves |
| collection | DOAJ |
| description | Objective. Factors linked with insulin resistance were examined for their association with large-for-gestational-age (LGA) infant birth weight and gestational diabetes. Study Design. Data came from a longitudinal cohort study of 2,305 subjects without overt diabetes, analyzed using multinomial logistic and linear regression. Results. High maternal BMI (OR=1.53 (1.11, 2.12)), height (1.98 (1.62, 2.42)), antidepressant use (1.71 (1.20, 2.44)), pregnancy weight-gain exceeding 40 pounds (1.79 (1.25, 2.57)), and high blood sugar (2.68, (1.53, 5.27)) were all positively associated with LGA birth. Strikingly, the difference in risk from diagnosed and treated gestational diabetes compared to women with a single abnormal glucose tolerance test (but no diagnosis of gestational diabetes) was significant (OR=0.65, p=0.12 versus OR=2.84, p<0.01). When weight/length ratio was used instead, different factors were found to be significant. BMI and pregnancy weight-gain were found to influence the development of gestational diabetes, through an additive interaction. Conclusions. High prepregnancy BM, height, antidepressant use, pregnancy weight-gain exceeding 40 pounds, and high blood sugar were associated with LGA birth, but not necessarily infant weight/length ratio. An additive interaction between BMI and pregnancy weight-gain influenced gestational diabetes development. |
| format | Article |
| id | doaj-art-a80ab2e3a1f84c5183c6134b3b43f2dc |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-a80ab2e3a1f84c5183c6134b3b43f2dc2025-02-03T07:24:41ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/847674847674The Impact of Abnormal Glucose Tolerance and Obesity on Fetal GrowthErin Graves0David J. Hill1Susan Evers2Kristine Van Aarsen3Brie Yama4Su Yuan5M. Karen Campbell6Department of Epidemiology and Biostatistics, Western University, London, ON, N6A 5C1, CanadaDepartment of Physiology and Pharmacology, Western University, London, ON, N6A 5C1, CanadaDepartment of Family Relations and Applied Nutrition, Guelph, ON, N1G 2W1, CanadaDepartment of Epidemiology and Biostatistics, Western University, London, ON, N6A 5C1, CanadaDepartment of Epidemiology and Biostatistics, Western University, London, ON, N6A 5C1, CanadaDepartment of Epidemiology and Biostatistics, Western University, London, ON, N6A 5C1, CanadaDepartment of Epidemiology and Biostatistics, Western University, London, ON, N6A 5C1, CanadaObjective. Factors linked with insulin resistance were examined for their association with large-for-gestational-age (LGA) infant birth weight and gestational diabetes. Study Design. Data came from a longitudinal cohort study of 2,305 subjects without overt diabetes, analyzed using multinomial logistic and linear regression. Results. High maternal BMI (OR=1.53 (1.11, 2.12)), height (1.98 (1.62, 2.42)), antidepressant use (1.71 (1.20, 2.44)), pregnancy weight-gain exceeding 40 pounds (1.79 (1.25, 2.57)), and high blood sugar (2.68, (1.53, 5.27)) were all positively associated with LGA birth. Strikingly, the difference in risk from diagnosed and treated gestational diabetes compared to women with a single abnormal glucose tolerance test (but no diagnosis of gestational diabetes) was significant (OR=0.65, p=0.12 versus OR=2.84, p<0.01). When weight/length ratio was used instead, different factors were found to be significant. BMI and pregnancy weight-gain were found to influence the development of gestational diabetes, through an additive interaction. Conclusions. High prepregnancy BM, height, antidepressant use, pregnancy weight-gain exceeding 40 pounds, and high blood sugar were associated with LGA birth, but not necessarily infant weight/length ratio. An additive interaction between BMI and pregnancy weight-gain influenced gestational diabetes development.http://dx.doi.org/10.1155/2015/847674 |
| spellingShingle | Erin Graves David J. Hill Susan Evers Kristine Van Aarsen Brie Yama Su Yuan M. Karen Campbell The Impact of Abnormal Glucose Tolerance and Obesity on Fetal Growth Journal of Diabetes Research |
| title | The Impact of Abnormal Glucose Tolerance and Obesity on Fetal Growth |
| title_full | The Impact of Abnormal Glucose Tolerance and Obesity on Fetal Growth |
| title_fullStr | The Impact of Abnormal Glucose Tolerance and Obesity on Fetal Growth |
| title_full_unstemmed | The Impact of Abnormal Glucose Tolerance and Obesity on Fetal Growth |
| title_short | The Impact of Abnormal Glucose Tolerance and Obesity on Fetal Growth |
| title_sort | impact of abnormal glucose tolerance and obesity on fetal growth |
| url | http://dx.doi.org/10.1155/2015/847674 |
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